Lipids as Regulators of Inflammation and Tissue Regeneration

Details

• Personal Author:
  Badylak SF ; Hussey GS ; Kagan VE ; Kapralov AA ; Shvedova AA ; Timashev PS ; Tyurin VA ; Tyurina YY ; Badylak SF ; Hussey GS ; Kagan VE ; Kapralov AA ; Shvedova AA ; Timashev PS ; Tyurin VA ; Tyurina YY
• Description:
  Inflammation is a homeostatic defensive reprogramming in response to harmful stimuli such as pathogens or tissue insults causing cell damage or death. When tissue injury is caused by trauma, ischemia-reperfusion or chemical agents in the absence of infection, or the implantation of a sterile medical device or biomaterial, the inflammatory response is called sterile inflammation. In addition to its role in mitigating infections, inflammation is important for clearing damaged cells and initiating tissue repair. Inflammatory mechanisms are evolutionary conserved and function not only in mammals but also in lower organisms. Inflammation has to be balanced as insufficient inflammation is associated with unresolved tissue destruction, whereas chronic unresolved inflammation can lead to a variety of pathologies, including cancer and fibrosis. Modulation of the inflammatory response requires an understanding of the signaling molecules and initiators involved in the process. [Description provided by NIOSH]
• Subjects:
  Immune System Lipids Occupational Health Pathology Safety
• Keywords:
  Immune system; Immune reaction; Lipids; Chronic inflammation; Pathology; Molecular signaling; Cell biology; Phospholipids; Hydrolysis
• DOI:
  https://doi.org/10.1016/B978-0-12-821440-4.00005-0
• ISBN:
  9780128214404
• Publisher:
  Elsevier Ltd.
• Document Type:
  Text
• Genre:
  Book ; Book
• Place as Subject:
  Maryland ; OSHA Region 3 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  175-193
• NIOSHTIC Number:
  nn:20065005
• Citation:
  Immunomodulatory biomaterials: regulating the immune response with biomaterials to affect clinical outcome. Badylak SF, Elisseeff JH, eds. Duxford, United Kingdom: Elsevier Ltd., 2021 Jul; :175-193
• Contact Point Address:
  Yulia Y Tyurina, Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, United States
• Editor(s):
  Badylak SF; Elisseeff JH ; Badylak SF; Elisseeff JH
• Federal Fiscal Year:
  2021
• Peer Reviewed:
  False
• Source Full Name:
  Immunomodulatory biomaterials: regulating the immune response with biomaterials to affect clinical outcome
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3e385f77b8c8deae4d8a0411ef874fbafd72e77bce1a7b14bb42126e7639cfb1cf0c32806a8fc4ede9248c6441be731185df8f5aa55607b05b3845489946bad3
• Download URL:
  https://stacks.cdc.gov/view/cdc/248905/cdc_248905_DS1.pdf
• File Type:
  [PDF - 786.66 KB ]