Immunological effects of gulf oil spill: crude oil, COREXIT® EC9500A dispersant and oil/dispersant mixtures.

Details

• Personal Author:
  Anderson, Stacey E. ; Barbero AM ; Franko J ; Frasch, H. Fredrick ; Lukomska E ; Meade BJ ; Munson AE
• Description:
  Workers involved in the gulf oil spill containment and cleanup efforts have reported health concerns including pulmonary distress, dermatological problems, and an increased incidence of infection. These concerns have prompted toxicological evaluation of samples recovered from the gulf oil spill including: COREXIT EC9500A (CR), crude oil and crude oil/CR mixtures. Potential for hypersensitivity and immune suppression were evaluated in dermal exposure murine models. Dermal exposure to 50 µl of CR for 3 days induced irritation and significant increases in lymphocyte proliferation at concentrations of 10% and greater, while exposure to oil induced significant elevations in lymphocyte proliferation at concentrations of > / = 50%. No alterations in serum IgE were observed after exposure to either test article. Exposure to crude oil was also found to be immunosuppressive. The spleen IgM response to sheep red blood cells was significantly inhibited when mice were exposed to 50 µl at concentrations of > / = 25% crude oil for 14-days. Increased liver and decreased spleen weights were also documented. Mixtures of crude oil and CR did not enhance either effect. Consistent with these results, CR did not enhance in vitro epidermal penetration of naphthalene. These studies suggest potential immunological effects from dermal exposure to crude oil and CR. [Description provided by NIOSH]
• Subjects:
  Digestive System Digestive System Diseases Immune System Liver Occupational Health Safety Skin
• Keywords:
  In-vitro-studies; Crude-oil; Immune-reaction; Immunology; Immunologic-disorders; Skin-exposure; Liver-damage; Liver-function
• ISSN:
  0892-6638
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  25
• NIOSHTIC Number:
  nn:20038539
• Citation:
  FASEB J 2011 Apr; 25(Meeting Abstracts):1016.5
• CAS Registry Number:
  1-(1-Butoxy-2-propoxy)-2-propanol (CAS RN 29911-28-2) ; Distillates (petroleum), hydrotreated light (CAS RN 64742-47-8) ; Polyethylene glycol sorbitan trioleate (CAS RN 9005-70-3) ; Polyoxyethylene sorbitan monooleate (CAS RN 9005-65-6) ; Sodium bis(2-ethylhexyl) sulfosuccinate (CAS RN 577-11-7) ; Sorbitan mono-(9Z)-9-octadecenoate (CAS RN 1338-43-8)
• Federal Fiscal Year:
  2011
• Peer Reviewed:
  False
• Source Full Name:
  The FASEB Journal
• Supplement:
  Meeting Abstracts
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/248126/cdc_248126_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]