Effect of sleep-wake cycle reversal on luteinizing hormone secretory pattern in puberty.

Details

• Personal Author:
  Boyar RM ; Finkelstein JW ; Hellman L ; Kapen S ; Weitzman ED
• Description:
  An investigation of the effects of an acute 180 degree reversal of the sleep/wake cycle on luteinizing hormone (LH) secretion was studied in three pubertal boys and the data collected was combined with that from the study of a fourth boy. Two 24 hour periods of blood sampling every 20 minutes were carried out in each of the boys, aged 14 to 15 years. The first study was conducted during a normal sleep/wake cycle and the second was during an acute sleep/wake reversal for three subjects and a sleep delay pattern for one. Polygraphically defined nocturnal sleep was associated with a marked rise in plasma LH concentration. After acute reversal of the sleep/wake cycle, LH secretion was clearly enhanced during the daytime sleep period. The LH plasma concentration increased immediately following sleep onset. These findings support a strong correlation between sleep stage and LH secretion in pubertal subjects. In the comparison study the daytime waking period was characterized by low concentrations of LH and relatively small episodic fluctuations. The plasma concentrations of LH remained elevated during nocturnal waking, as opposed to daytime waking, showing that acute sleep/wake reversal did not eliminate increased LH secretion at night in pubertal subjects. [Description provided by NIOSH]
• Subjects:
  Age Factors Endocrine System Occupational Health Safety Sleep Sleep Initiation And Maintenance Disorders Urogenital System
• Keywords:
  NIOSH-Publication; NIOSH-Grant; Grants-other; Sleep-deprivation; Reproductive-system; Age-factors; Hormone-activity; Humans
• ISSN:
  0021-972X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maine ; New York ; OSHA Region 1 ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  293-299
• Volume:
  39
• Issue:
  2
• NIOSHTIC Number:
  nn:00190560
• Citation:
  J Clin Endocrinol Metab 1974 Aug; 39(2):293-299
• Contact Point Address:
  Division of Neurology Montefiore Hosp and Med Center Division of Neurology Bronx, N Y 10467
• Federal Fiscal Year:
  1974
• NORA Priority Area:
  Grants Other
• Performing Organization:
  Montefiore Hospital and Medical Center, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19710601
• Source Full Name:
  Journal of Clinical Endocrinology and Metabolism
• End Date:
  19761231
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/247709/cdc_247709_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]