Role of Sleep and Sleep Loss in Hormonal Release and Metabolism

Details

• Personal Author:
  Leproult R ; Van Cauter E
• Description:
  Compared to a few decades ago, adults, as well as children, sleep less. Sleeping as little as possible is often seen as an admirable behavior in contemporary society. However, sleep plays a major role in neuroendocrine function and glucose metabolism. Evidence that the curtailment of sleep duration may have adverse health effects has emerged in the past 10 years. Accumulating evidence from both epidemiologic studies and well-controlled laboratory studies indicates that chronic partial sleep loss may increase the risk of obesity and weight gain. The present chapter reviews epidemiologic studies in adults and children and laboratory studies in young adults indicating that sleep restriction results in metabolic and endocrine alterations, including decreased glucose tolerance, decreased insulin sensitivity, increased evening concentrations of cortisol, increased levels of ghrelin, decreased levels of leptin and increased hunger and appetite. Altogether, the evidence points to a possible role of decreased sleep duration in the current epidemic of obesity. Bedtime extension in short sleepers should be explored as a novel behavioral intervention that may prevent weight gain or facilitate weight loss. Avoiding sleep deprivation may help to prevent the development of obesity, particularly in children. [Description provided by NIOSH]
• Subjects:
  Behavior Circadian Rhythm Occupational Health Safety Sleep Sleep Initiation And Maintenance Disorders
• Keywords:
  Behavior Patterns Children Circadian Rhythms Endocrine System Disorders Metabolic Disorders Obesity Sleep Deprivation Sleep Disorders
• ISSN:
  1421-7082
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  11-21
• Volume:
  17
• NIOSHTIC Number:
  nn:20052794
• Citation:
  Endocr Dev 2010 Jan; 17:11-21
• Contact Point Address:
  Eve Van Cauter, PhD, Department of Medicine, MC1027, 5841 S. Maryland Avenue, Chicago, IL 60637
• Email:
  evcauter@medicine.bsd.uchicago.edu
• Federal Fiscal Year:
  2010
• NORA Priority Area:
  Healthcare and Social Assistance
• Performing Organization:
  University of Chicago
• Peer Reviewed:
  True
• Start Date:
  20090901
• Source Full Name:
  Endocrine Development
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:733b15541119ddda8eb44410f32a04292438642812807e557d92bb1e89a8418dd1624504c21fe4d8d51334593216241035c0e127f5fab086da87ab38b2775f79
• Download URL:
  https://stacks.cdc.gov/view/cdc/212267/cdc_212267_DS1.pdf
• File Type:
  [PDF - 163.73 KB ]