Developmental neurotoxicology of in utero exposure to industrial solvents in experimental animals.

Details

• Personal Author:
  Nelson BK
• Description:
  Literature was reviewed on the developmental neurotoxicity of the following industrial solvents after exposure in-utero: carbon- disulfide (75150), chloroform (67663), formaldehyde (50000), glycol- ethers, methyl-chloroform (71556), methyl-n-butyl-ketone (591786), methylene-chloride (75092), perchloroethylene (127184), n-propanol (71238), and tertiary-butanol (75650). All of these solvents were administered during pregnancy, and functional testing was carried out on the offspring. Species of test animal, dose, route and time of exposure, and the postnatal functions evaluated were presented, as well as observed effects. Although comparatively few solvents have been evaluated for developmental neurotoxicology, most of these solvents produced significant differences from controls in animals. Many studies used the inhalation route of exposure, which is the route most often encountered in occupational or environmental exposure. Most studies extended the exposure for the majority of gestation of rats. Additional testing of industrial solvents was strongly recommended. [Description provided by NIOSH]
• Subjects:
  Behavior Fetus Laboratories Nervous System Occupational Health Safety Solvents Teratogenesis Urogenital System
• Keywords:
  NIOSH-Author; Teratogenicity; Transplacental-exposure; Organic-solvents; Neurotoxic-effects; Fetus; Laboratory-animals; Behavioral-testing
• ISSN:
  0161-813X
• Document Type:
  Text
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  441-448
• Volume:
  7
• Issue:
  2
• NIOSHTIC Number:
  nn:00165221
• Citation:
  Neurotoxicology 1986 Jan; 7(2):441-448
• CAS Registry Number:
  1,1,1-Trichloroethane (CAS RN 71-55-6) ; 1-Propanol (CAS RN 71-23-8) ; 2-Hexanone (CAS RN 591-78-6) ; Carbon disulfide (CAS RN 75-15-0) ; Chloroform (CAS RN 67-66-3) ; Dichloromethane (CAS RN 75-09-2) ; Formaldehyde (CAS RN 50-00-0) ; tert-Butanol (CAS RN 75-65-0) ; Tetrachloroethylene (CAS RN 127-18-4)
• Federal Fiscal Year:
  1986
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects
• Peer Reviewed:
  True
• Source Full Name:
  Neurotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/247581/cdc_247581_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]