Neurochemical, but not behavioral, deviations in the offspring of rats following prenatal or paternal inhalation exposure to ethanol.

Details

• Personal Author:
  Brightwell WS ; Burg, Jeanne R. ; Mackenzie-Taylor DR ; Massari VJ ; Nelson BK
• Description:
  Possible effects on offspring from parental ethanol (64175) exposure were studied in male and female Sprague-Dawley-rats exposed at levels of 16000 and 10000 parts per million (ppm). Rats were exposed by inhalation for 7 hours a day; males were exposed for 6 weeks, while females were exposed through gestation. Exposed rats were mated with untreated rats. Litters were fostered to unexposed dams within 16 hours after birth. Offspring were tested for neuromotor coordination, activity level, and learning ability. At 21 days of age, pups were analyzed for neurochemical changes. Exposure to the higher concentration produced slight maternal toxicity as evidenced by a reduction in feed intake. No effect was noted on fertility and weight gain was not significantly affected by either concentration. No change in water consumption nor in litter size, number of dead pups, or length of pregnancy was noted. Neuromuscular abilities were similar to those in control rats. There were significant changes in biochemical effects as evidenced in noradrenergic, serotonergic, and m-enkephalinergic brain systems. As the enkephalins are widely distributed neurotransmitters and neurohormones found in the brain, spinal cord, pituitary, adrenal medulla, autonomic nervous system, and gastrointestinal tract, changes in their concentration may influence many functions. The authors conclude that inhalation exposure to ethanol does not produce behavioral teratogenic effects in rats, but does produce neurochemical alterations. [Description provided by NIOSH]
• Subjects:
  Behavior Fetus Occupational Health Safety Solvents Teratogenesis Urogenital Diseases Urogenital System
• Keywords:
  Alcohols Behavioral-testing Organic-solvents Reproductive-hazards Teratogens Transplacental-exposure
• ISSN:
  0892-0362
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  District of Columbia ; Ohio ; OSHA Region 3 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  15-22
• Volume:
  10
• Issue:
  1
• NIOSHTIC Number:
  nn:00180731
• Citation:
  Neurotoxicol Teratol 1988 Jan; 10(1):15-22
• CAS Registry Number:
  Ethanol (CAS RN 64-17-5)
• Federal Fiscal Year:
  1988
• Peer Reviewed:
  True
• Source Full Name:
  Neurotoxicology and Teratology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3314a6a779c0a7e7aba6a665035dd3ff562a618bfb8678eccb173808c01cf92f1b0e280e3a91aebdea818b2574f7082ccaad5c0b4bc09dcb40697ac2383255c6
• Download URL:
  https://stacks.cdc.gov/view/cdc/185558/cdc_185558_DS1.pdf
• File Type:
  [PDF - 837.78 KB ]