Multiple short-term effects of lead on the renin-angiotensin system.

Details

• Personal Author:
  Goldman JM ; Keiser J ; Mouw DR ; Nicholls MG ; Vander AJ
• Description:
  The effects of lead (7439921) on the relationship between plasma renin and angiotensin II were studied. Male dogs were catheterized to measure hepatic renal flow and plasma renin activity. The effects of lead, 0.5 milligrams per minute, administered by continuous infusion for 3 hours, on these parameters and on arterial angiotensin II were measured. In some animals the effect of lead on the hepatic removal of renin was monitored by sampling hepatic portal blood. Plasma renin activity rose significantly over the 3 hour period of lead exposure. Although there was a linear relationship between angiotensin II levels and plasma renin activity following nonlead stimuli, this relation was changed with lead lowered angiotensin II levels. Hepatic removal of renin was shut off after 2 to 3 hours of lead administration. The authors conclude that the major cause of increased plasma renin activity after lead administration is the cessation of hepatic removal of renin and lead prevents angiotensin II levels from rising proportionately with plasma renin activity. [Description provided by NIOSH]
• Subjects:
  Animals Blood Hematologic Tests Immune System Lead Lead Poisoning Metals, Heavy Occupational Health Safety Toxicology
• Keywords:
  NIOSH-Publication; NIOSH-Grant; Heavy-metals; Hematology; Animal-studies; Toxicology; Immunology; Kidney-function; Lead-poisoning; Blood-plasma
• ISSN:
  0022-2143
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  251-263
• Volume:
  97
• Issue:
  2
• NIOSHTIC Number:
  nn:00122211
• Citation:
  J Lab Clin Med 1981 Feb; 97(2):251-263
• Contact Point Address:
  Physiology University of Michigan 6811 Medical Science II Ann Arbor, Mich
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  1981
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other
• Performing Organization:
  University of Michigan at Ann Arbor, Ann Arbor, Michigan
• Peer Reviewed:
  True
• Start Date:
  19790901
• Source Full Name:
  The Journal of Laboratory and Clinical Medicine
• End Date:
  19830831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/247520/cdc_247520_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]