Lead, hypertension, and the renin-angiotensin system in rats.

Details

• Personal Author:
  Schoeps P ; Shulak JM ; SJulius S ; Vander AJ ; Victery W
• Description:
  The effect of lead (7439921) exposure on the production of hypertension and on the renin angiotensin system (RAS) was investigated in rats. Pregnant Charles-River-rats were fed water containing 0, 100 or 500 parts per million (ppm) lead during pregnancy and lactation. The regimen was continued after weaning. Blood pressure recordings were obtained monthly in all male offspring by the tail cuff method. Animals were sacrificed at 6 months of age to evaluate the RAS in a basal state. Some animals were subjected to pentobarbital anesthesia, laparotomy and aortic puncture to permit evaluation of the effect of lead on plasma renin activity (PRA) during stimulated renin release. Rats that received 100ppm of lead developed a significant elevation of systolic blood pressure; rats that received 500ppm remained normotensive. The PRA was significantly reduced after 6 months in males receiving 100ppm lead; PRA was normal in the 500ppm group. The authors conclude that blood lead values commonly encountered in individuals are capable of inducing moderate hypertension in male rats while higher doses failed to do so. They suggest that since the hypertension is associated with a reduction in PRA, it is unlikely to be due to hyperactivity of the RAS. [Description provided by NIOSH]
• Subjects:
  Blood Cardiovascular Diseases Cardiovascular System Hematologic Tests Laboratories Lead Lead Poisoning Metals, Heavy Occupational Health Safety Toxicology

  More +
• Keywords:
  NIOSH-Publication; NIOSH-Grant; Cardiovascular-system-disorders; Heavy-metals; Hypertension; Laboratory-animals; Toxicology; Hematology; Lead-poisoning; Blood-plasma
• ISSN:
  0022-2143
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maine ; Michigan ; OSHA Region 1 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  354-362
• Volume:
  99
• Issue:
  3
• NIOSHTIC Number:
  nn:00122681
• Citation:
  J Lab Clin Med 1982 Mar; 99(3):354-362
• Contact Point Address:
  Physiology University of Michigan 6811 Medical Science II Ann Arbor, Mich
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  1982
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other
• Performing Organization:
  University of Michigan at Ann Arbor, Ann Arbor, Michigan
• Peer Reviewed:
  True
• Start Date:
  19790901
• Source Full Name:
  The Journal of Laboratory and Clinical Medicine
• End Date:
  19830831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/247521/cdc_247521_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]