Alterations in hepatocytes after manipulation of the diet: copper, zinc and cadmium interactions.

Details

• Personal Author:
  Basom CR ; Miller ML ; Murthy L ; Petering HG
• Description:
  Morphometric analyses of liver parenchymal cells are performed on ale albino rats fed a semipurified diet supplemented with two levels of copper (7440508) and zinc (7440666). The metals are administered in demineralized drinking water to four groups of animals at two levels. Cadmium (7440439) is also administered in the drinking water daily to one group of rats. Hepatocytes from rats fed the semipurified diet with low copper and zinc plus cadmium show a significant increase in smooth endoplasmic reticulum compared to animals fed the semipurified diet alone. Smooth endoplasmic reticulum increases when diets include chow and cadmium whereas rough endoplasmic reticulum decreases. [Description provided by NIOSH]
• Subjects:
  Cytology Food Contamination Liver Metals Occupational Health Poisoning Safety
• Keywords:
  NIOSH-Publication; NIOSH-Grant; Liver-disorders; Metal-poisoning; Water-contamination; Morphology; Cytopathology; Food-contamination
• ISSN:
  0002-9106
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  23-39
• Volume:
  141
• Issue:
  1
• NIOSHTIC Number:
  nn:00036271
• Citation:
  Am J Anat 1974 Sep; 141(1):23-39
• Contact Point Address:
  Environmental Health Kettering Laboratory Eden & Bethesda Avenues Cincinnati, Ohio 45219
• CAS Registry Number:
  Cadmium (CAS RN 7440-43-9) ; Copper (CAS RN 7440-50-8) ; Zinc (CAS RN 7440-66-6)
• Federal Fiscal Year:
  1974
• Performing Organization:
  University of Cincinnati, Cincinnati, Ohio
• Peer Reviewed:
  True
• Start Date:
  19700901
• Source Full Name:
  American Journal of Anatomy
• End Date:
  19790831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/247388/cdc_247388_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]