Toxicity of metal ions to alveolar macrophages.

Details

• Personal Author:
  Bowman L ; Castranova, Vincent ; Miles PR ; Reasor MJ
• Description:
  The effects of metallic ions and solvents on the function of alveolar macrophages (AM) were studied. AM from male Long-Evans- hooded-rats were incubated with or without cadmium (7440439) (Cd), mercury (7439976) (Hg), nickel (7440020) (Ni), lead (7439921) (Pb), aluminum (7429905) (Al), chromium (7440473) (Cr), or iron (7439896) (Fe) ions, or carbon-tetrachloride (56235), toluene (108883), or xylene (1330207), and AM functional responses were measured. Oxygen (O2) consumption and chemiluminescence were the AM functions most sensitive to metal effects. Metal ions decreased O2 consumption by 70 to 90 percent; Hg was the most potent inhibitor followed in decreasing order by Al, Fe, Cd, Pb, Cr, and Ni. In decreasing order of effectiveness, release of superoxide anions by AM was inhibited 70 to 85 percent by Hg, Ni, Cd, Pb, Al, Fe, and Cr. Carbon- tetrachloride, toluene, and xylene did not significantly inhibit superoxide anion release, but O2 consumption was decreased 74, 67, and 72 percent, respectively. The integrity of AM cell membranes was not affected in 90 percent of cells by high concentrations of metal ions. The authors conclude that exposure to metallic ions and solvents is toxic to the AM of rats. [Description provided by NIOSH]
• Subjects:
  Cytology Cytotoxins Laboratories Metals Metals, Heavy Occupational Health Poisoning Safety Toxicology
• Keywords:
  Comparative-toxicology Cytotoxicity Heavy-metals Laboratory-animals Metallic-poisoning Metallic-poisons NIOSH-Author
• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  349-357
• Volume:
  1
• Issue:
  3
• NIOSHTIC Number:
  nn:00116648
• Citation:
  Am J Ind Med 1980; 1(3):349-357
• CAS Registry Number:
  Aluminum (CAS RN 7429-90-5) ; Cadmium (CAS RN 7440-43-9) ; Carbon tetrachloride (CAS RN 56-23-5) ; Chromium (CAS RN 7440-47-3) ; Iron (CAS RN 7439-89-6) ; Lead (CAS RN 7439-92-1) ; Mercury (CAS RN 7439-97-6) ; Nickel (CAS RN 7440-02-0) ; Toluene (CAS RN 108-88-3) ; Xylene (CAS RN 1330-20-7)
• Federal Fiscal Year:
  1980
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9e3f4ab409132f83056b9d04eefee362b85572421ad3fa84af70b05d2feab879ada1396c92fa448689caa72a4a9d88431967d32fda771fc71bd237cceddf82e3
• Download URL:
  https://stacks.cdc.gov/view/cdc/184453/cdc_184453_DS1.pdf
• File Type:
  [PDF - 508.26 KB ]