Erythrocyte lead-binding protein after occupational exposure. II. Influence on lead inhibition of membrane Na+,K+-adenosinetriphosphatase.

Details

• Personal Author:
  Culver BD ; Gonick HC ; Raghavan SRV
• Description:
  The relationship between red blood cell membrane concentrations of lead (7439921) and activities of sodium-potassium-adenosinetriphosphatase (Na+,K+-ATPase) was investigated. Erythrocytes were prepared from blood samples taken from 8 normal human subjects, 14 lead exposed workers without lead poisoning, 5 exposed workers with lead poisoning and high blood lead concentrations, and 5 exposed workers with lead poisoning and low blood lead concentrations. Lead concentrations in various erythrocytic fractions were determined, and membrane Na+,K+-ATPase activity was measured. An inverse correlation was found between membrane lead concentrations and Na+,K+-ATPase activity, but no relationship existed between enzyme activity and total erythrocytic lead. The residual lead in the red blood cells was evenly divided between a high molecular weight protein and the membrane. The authors suggest that the primary determinant of lead toxicity in a given cell is the distribution of lead among nontoxic binding proteins and compartments that contain susceptible enzyme systems. [Description provided by NIOSH]
• Subjects:
  Cytology Enzymes Hematologic Tests Lead Lead Poisoning Metals, Heavy Occupational Health Poisoning Safety
• Keywords:
  Cell Biology Chemical Binding Enzyme Activity Heavy Metals Hematology Lead Poisoning
• ISSN:
  0098-4108
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  7
• Issue:
  3
• NIOSHTIC Number:
  nn:00114132
• Citation:
  J Toxicol Environ Health 1981 Mar-Apr; 7(3-4):561-568
• Contact Point Address:
  Harvey C. Gonick, Department of Medicine and Trace Element Laboratory, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, California 90048
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  1981
• Performing Organization:
  University of California San Francisco
• Peer Reviewed:
  True
• Start Date:
  19770701
• Source Full Name:
  Journal of Toxicology and Environmental Health
• End Date:
  19790630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b79cbd7bad56ce7a70baf2991a1f0daad80fcd355db35c80c62e2d990fa37a909678d4da96ffb40e74f11d61622d25d23196f1797fade5b4b8956db90ccf7611
• Download URL:
  https://stacks.cdc.gov/view/cdc/184421/cdc_184421_DS1.pdf
• File Type:
  [PDF - 578.49 KB ]