Details:

Alternative Title:
J Exp Med
Personal Author:
Angela Montesano, M. ; Colley, Daniel G. ; Eloi-Santos, Silvana ; Freeman, George L. ; Secor, W. Evan
Angela Montesano, M. ; Colley, Daniel G. ; Eloi-Santos, Silvana ; Freeman, George L. ; Secor, W. Evan Less -
Description:
Exposure to maternal idiotypes (Ids) or antigens might predispose a child to develop an immunoregulated, asymptomatic clinical presentation of schistosomiasis. We have used an experimental murine system to address the role of Ids in this immunoregulation. Sera from mice with 8-wk Schistosoma mansoni infection, chronic (20-wk infection) moderate splenomegaly syndrome (MSS), or chronic hypersplenomegaly syndrome (HSS) were passed over an S. mansoni soluble egg antigen (SEA) immunoaffinity column to prepare Ids (8WkId, MSS Id, HSS Id). Newborn mice were injected with 8WkId, MSS Id, HSS Id, or normal mouse immunoglobulin (NoMoIgG) and infected with S. mansoni 8 wk later. Mice exposed to 8WkId or MSS Id as newborns had prolonged survival and decreased morbidity compared with mice that received HSS Id or NoMoIgG. When stimulated with SEA, 8WkId, or MSS Id, spleen cells from mice neonatally injected with 8WkId or MSS Id produced more interferon gamma than spleen cells from mice neonatally injected with HSS Id or NoMoIgG. Furthermore, neonatal exposure to 8WkId or MSS Id, but not NoMoIgG or HSS Id, led to significantly smaller granuloma size and lower hepatic fibrosis levels in infected mice. Together, these results indicate that perinatal exposure to appropriate anti-SEA Ids induces long-term effects on survival, pathology, and immune response patterns in mice subsequently infected with S. mansoni.
Subjects:
[+]
Animals Animals, Newborn Antibodies, Helminth Antigens, Helminth Disease Models, Animal Disease Progression Fibrosis Granuloma Immunity, Maternally-Acquired Immunization, Passive Immunoglobulin Idiotypes Interferon-gamma Liver Male Mice Mice, Inbred CBA Organ Size Schistosoma Mansoni Schistosomiasis Mansoni Spleen Splenomegaly
Source:
J Exp Med. 1999; 189(4):637-645.
Document Type:
Journal Article
Funding:
AI-11289/AI/NIAID NIH HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:4709527a04d09ca055c677b811a5751a0ae413f6c157c48691a2f6b35ba5defd
Download URL:
https://stacks.cdc.gov/view/cdc/24523/cdc_24523_DS1.pdf
File Type:

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