Details:

Alternative Title:
Int J Parasitol
Personal Author:
Pereira, Thiago Almeida ; Syn, Wing-Kin ; Pereira, Fausto E.L. ; Lambertucci, José Roberto ; Secor, William Evan ; ... More +
Pereira, Thiago Almeida ; Syn, Wing-Kin ; Pereira, Fausto E.L. ; Lambertucci, José Roberto ; Secor, William Evan ; Diehl, Anna Mae ; Less -
Description:
Schistosomiasis is a major cause of fibrosis and portal hypertension. The reason 4-10% of infected subjects develops hepatosplenic schistosomiasis remains unclear. Chronically infected male CBA/J mice reproduce the dichotomic forms of human schistosomiasis. Most mice (80%) develop moderate splenomegaly syndrome (similar to hepatointestinal disease in humans) and 20% present severe hypersplenomegaly syndrome (analogous to human hepatosplenic disease). We demonstrated that the profibrogenic molecule osteopontin discriminates between mice with severe and mild disease and could be a novel morbidity biomarker in murine and human schistosomiasis. Failure to downregulate osteopontin during the chronic phase may explain why hepatosplenic subjects develop severe fibrosis.
Subject:
[+]
Analysis Of Variance
Animals
Article
Biomarker
Biomarkers
Disease Models, Animal
Fibrosis
Humans
Hypertension, Portal
Intestinal Diseases, Parasitic
Liver Cirrhosis
Liver Fibrosis
Longitudinal Studies
Male
Mice
Mice, Inbred CBA
Osteopontin
Portal Hypertension
ROC Curve
Schistosomiasis Mansoni
Splenomegaly

Source:
Int J Parasitol. 46(13-14):829-832. ;
Pubmed ID:
27729270
Pubmed Central ID:
PMC5584370
Document Type:
Journal Article ;
Funding:
CC999999/Intramural CDC HHS/United States ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:94db5f81e261d7aed7c814c968382dcb46dfc271ee37feb4e4832e6baf43d52d
File Type:

Supporting Files

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