Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni

Pereira, Thiago Almeida; Syn, Wing-Kin; Pereira, Fausto E.L.; Lambertucci, José Roberto; Secor, William Evan; Diehl, Anna Mae

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Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni

Published Date:

Oct 10 2016

Source:

Int J Parasitol. 46(13-14):829-832.

[PDF-216.65 KB]

Details:

Alternative Title:

Int J Parasitol

Personal Author:

Pereira, Thiago Almeida ; Syn, Wing-Kin ; Pereira, Fausto E.L. ; Lambertucci, José Roberto ; Secor, William Evan ; ... More ▼

Description:

Schistosomiasis is a major cause of fibrosis and portal hypertension. The reason 4-10% of infected subjects develops hepatosplenic schistosomiasis remains unclear. Chronically infected male CBA/J mice reproduce the dichotomic forms of human schistosomiasis. Most mice (80%) develop moderate splenomegaly syndrome (similar to hepatointestinal disease in humans) and 20% present severe hypersplenomegaly syndrome (analogous to human hepatosplenic disease). We demonstrated that the profibrogenic molecule osteopontin discriminates between mice with severe and mild disease and could be a novel morbidity biomarker in murine and human schistosomiasis. Failure to downregulate osteopontin during the chronic phase may explain why hepatosplenic subjects develop severe fibrosis.

Subject:

[+]

Pubmed ID:

27729270

Pubmed Central ID:

PMC5584370

Document Type:

Journal Article

Funding:

CC999999/Intramural CDC HHS/United States

Collection(s):

CDC Public Access

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