Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Simmons, Marion M. ; Moore, S. Jo ; Konold, Timm ; Thurston, Lisa ; Terry, Linda A. ; ... More +
Simmons, Marion M. ; Moore, S. Jo ; Konold, Timm ; Thurston, Lisa ; Terry, Linda A. ; Thorne, Leigh ; Lockey, Richard ; Vickery, Chris ; Hawkins, Stephen A.C. ; Chaplin, Melanie J. ; Spiropoulos, John Less -
Description:
To investigate the possibility of oral transmission of atypical scrapie in sheep and determine the distribution of infectivity in the animals' peripheral tissues, we challenged neonatal lambs orally with atypical scrapie; they were then killed at 12 or 24 months. Screening test results were negative for disease-specific prion protein in all but 2 recipients; they had positive results for examination of brain, but negative for peripheral tissues. Infectivity of brain, distal ileum, and spleen from all animals was assessed in mouse bioassays; positive results were obtained from tissues that had negative results on screening. These findings demonstrate that atypical scrapie can be transmitted orally and indicate that it has the potential for natural transmission and iatrogenic spread through animal feed. Detection of infectivity in tissues negative by current surveillance methods indicates that diagnostic sensitivity is suboptimal for atypical scrapie, and potentially infectious material may be able to pass into the human food chain.
Subjects:
[+]
Alimentary System Animals Animals, Newborn Atypical Bioassay Brain Infectivity Mice Mice, Transgenic Oral Administration Prions And Related Diseases Research Scrapie Scrapie Agent Sheep
Source:
Emerg Infect Dis. 17(5):848-854.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:6f4a9454281f0fb3bb8d34b3b0b97a270500df3f1b9120e2f9f8137a360a369a
Download URL:
https://stacks.cdc.gov/view/cdc/24371/cdc_24371_DS1.pdf
File Type:

Supporting Files

• 	10-1654-vid1-pmcvs_normal.ogv	ogv
  	10-1654-vid1.gif	gif
  	10-1654-vid1.jpg	jpeg
  	10-1654-vid1.mp3	mp3
  	10-1654_finalR.nxml	txt
  	license.txt	txt
  	10-1654-F1.gif	gif
  	10-1654-F1.jpg	jpeg
  	10-1654-F2.gif	gif
  	10-1654-F2.jpg	jpeg
  	10-1654-F3.gif	gif
  	10-1654-F3.jpg	jpeg
  	10-1654-vid1-pmcvs_normal.mp3	mp3
  	10-1654-vid1-pmcvs_normal.ogg	ogg

More +