Isolation of Prion with BSE Properties from Farmed Goat

Spiropoulos, John; Lockey, Richard; Sallis, Rosemary E.; Terry, Linda A.; Thorne, Leigh; Holder, Thomas M.; Beck, Katy E.; Simmons, Marion M.

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Isolation of Prion with BSE Properties from Farmed Goat

Supporting Files Public Domain

Dec 2011
By Spiropoulos, John ; Lockey, Richard ; Sallis, Rosemary E. ; ...

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Alternative Title:

Emerg Infect Dis
Personal Author:

Spiropoulos, John ; Lockey, Richard ; Sallis, Rosemary E. ; Terry, Linda A. ; Thorne, Leigh ; Holder, Thomas M. ; Beck, Katy E. ; Simmons, Marion M.
Description:

Transmissible spongiform encephalopathies are fatal neurodegenerative diseases that include variant Creutzfeldt-Jakob disease in humans, scrapie in small ruminants, and bovine spongiform encephalopathy (BSE) in cattle. Scrapie is not considered a public health risk, but BSE has been linked to variant Creutzfeldt-Jakob disease. Small ruminants are susceptible to BSE, and in 2005 BSE was identified in a farmed goat in France. We confirm another BSE case in a goat in which scrapie was originally diagnosed and retrospectively identified as suspected BSE. The prion strain in this case was further characterized by mouse bioassay after extraction from formaldehyde-fixed brain tissue embedded in paraffin blocks. Our data show that BSE can infect small ruminants under natural conditions and could be misdiagnosed as scrapie. Surveillance should continue so that another outbreak of this zoonotic transmissible spongiform encephalopathy can be prevented and public health safeguarded.
Subjects:

Animals Animals, Domestic Biological Assay Bovine Spongiform Encephalopathy Brain Brain Chemistry Cattle Communicable Diseases, Emerging Encephalopathy, Bovine Spongiform Goat Diseases Goats Great Britain Humans Mice Mice, Inbred C57BL Mice, Transgenic Mouse Bioassay Podcast Prions Prions And Related Diseases PrPSc Proteins Research Scrapie Small Ruminant Transmissible Spongiform Encephalopathy Zoonoses
Source:

Emerg Infect Dis. 17(12):2253-2261.
Document Type:

Journal Article
Volume:

17
Issue:

12
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:957d362018191e2fd1290a25b306dba63dd55396003aa87b7796ba284de41f68
Download URL:

https://stacks.cdc.gov/view/cdc/23767/cdc_23767_DS1.pdf
File Type:

[PDF - 632.84 KB ]

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