Respiratory health effects of inhaled endotoxins: byssinosis and beyond.

Details

• Personal Author:
  Castellan, Robert M.
• Description:
  This overview considers clinical and epidemiological research relating to the theory that byssinosis, and symptoms associated with other organic dust exposures, may be caused by endotoxin inhalation. Evidence of a relationship between exposure to gram negative bacteria (GNB) and respiratory disease includes the outbreak of acute illnesses among individuals making mattresses from a low grade cotton that had been heavily contaminated. Recent studies suggest that endotoxin has a causal role, while providing evidence against a causal role for cotton bract in general and measured plant components. Monday chest symptoms have been correlated with airborne viable GNB concentrations and also with airborne endotoxin concentrations, but not with airborne dust concentrations. However, in other studies acute changes in lung function over the course of a Monday workshift showed a significant correlation with airborne dust concentrations, but not with either airborne GNB concentrations or with airborne endotoxins. While byssinosis has been traditionally restricted to workers with exposure to cotton, flax and hemp dust, there are similar effects among workers inhaling endotoxin contaminated dust in wool carpet factories, swine confinement centers, and animal feed mill facilities. The possible role of endotoxin in the etiology of hypersensitivity pneumonitis was also noted. The authors indicate that suggested limits for occupational exposure to airborne endotoxin can serve as a guideline for controlling exposures. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Animal Husbandry Animals Bacteria Dust Gossypium Inhalation Exposure Manufacturing And Industrial Facilities Occupational Exposure Occupational Health Particulate Matter Respiratory Tract Diseases Safety Textile Industry

  More +
• Keywords:
  Inhalants; Airborne-dusts; Dust-exposure; Organic-dusts; Textiles-industry; Bacterial-dusts; Animal-husbandry-workers; Respiratory-system-disorders; Cotton-mill-workers; Cotton-dust; Occupational-exposure
• ISBN:
  9780873716178
• Publisher:
  Lewis Publishers
• Document Type:
  Text
• Genre:
  Proceedings
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  97-100
• NIOSHTIC Number:
  nn:00237625
• Citation:
  Agricultural health and safety: workplace, environment, sustainability. McDuffie HH, Dosman JA, Semchuk KM, Olenchock SA, Senthilselvan A, eds. Boca Raton, FL: Lewis Publishers, 1995 Apr; :97-100
• Editor(s):
  McDuffie HH; Dosman JA; Semchuk KM; Olenchock SA; Senthilselvan A
• Federal Fiscal Year:
  1995
• NORA Priority Area:
  Pulmonary System Disorders
• Peer Reviewed:
  False
• Source Full Name:
  Agricultural health and safety: workplace, environment, sustainability
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/243574/cdc_243574_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]