NIOSH Testimony on Occupational Exposure to Methylene Chloride by J. D. Millar, September 21, 1992.

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  This testimony indicated that the present 500 part per million permissible exposure limit for methylene-chloride (75092) is not adequate to protect worker health, and supported the attempts of OSHA to lower the standard. Laboratory animal studies have indicated the carcinogenic potential of the compound. Three areas of concern related to the pharmacokinetics section of the OSHA proposed rule were discussed: unproven mechanistic assumptions made in physiologically based pharmacokinetic modeling; the impact of the variability in human metabolic parameters on the risk estimates; and the interpretation of a recent mechanistic study relevant to methylene-chloride risk assessment. Also discussed in this testimony were central nervous system health effects (short term exposure limit and prolonged neurobehavioral effects), studies of workers exposed to methylene-chloride, indirect evidence related to cardiovascular risk, estimates of carboxyhemoglobin levels in relation to methylene-chloride exposure, comparisons between the results of the animal and epidemiologic studies, exposure monitoring, control technology, respiratory protection and other protective clothing and equipment. NIOSH recommends that the exposure limit be reduced to the lowest feasible level. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no PDF
• Subjects:
  Carcinogens Cardiovascular Diseases Cardiovascular System Hydrocarbons Laboratories Nervous System Occupational Health Risk Assessment Risk Factors Safety Toxicology

  More +
• Keywords:
  NIOSH-Author; NIOSH-Testimony; Millar-J-D; Neurotoxic-effects; Carcinogens; Laboratory-animals; Risk-factors; Cardiovascular-system-disorders; Chlorinated-hydrocarbons; Comparative-toxicology
• Document Type:
  Text
• Genre:
  Testimony
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-19
• NIOSHTIC Number:
  nn:00214128
• NTIS Accession Number:
  PB93215176
• Citation:
  NIOSH 1992 Sep:19 pages
• CAS Registry Number:
  Dichloromethane (CAS RN 75-09-2)
• Federal Fiscal Year:
  1992
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects
• Peer Reviewed:
  False
• Source Full Name:
  NIOSH, 19 pages, 33 references
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/243266/cdc_243266_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]