NIOSH Skin Notation (SK) Profile: Endrin [CAS No. 72-20-8]

Details

• Alternative Title:
  NIOSH skin notation profile
• Personal Author:
  Dotson, G. Scott ; Hudson, Naomi L.
• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  No studies were identified that estimated the degree of endrin absorption through the skin
  
  however, acute and repeated-dose animal studies [Treon et al. 1955
  
  Gaines 1969] provide sufficient evidence that endrin has the potential to cause systemic effects, including nervous system effects and death. No human data or standard skin irritation tests were identified that evaluated the potential for skin irritation from endrin
  
  however, acute, repeated, and prolonged dermal exposure to endrin at low to high doses to intact and abraded skin of rabbits indicates that endrin is not likely to be irritating to the skin. No diagnostic tests in humans or predictive tests in animals were identified to adequately evaluate the potential of endrin alone to cause skin sensitization. Therefore, on the basis of these assessments, endrin is assigned a composite skin notation of SK: SYS (FATAL). Table 3 summarizes the skin hazard designations for endrin previously issued by NIOSH and other organizations. The equivalent dermal designation for endrin, according to the Globally Harmonized System (GHS) for the Classification and Labelling of Chemicals, is Acute Toxicity Category 3 (Hazard statement: Toxic in contact with the skin) [European Parliament 2008].
  
  Suggested citation: NIOSH [2015]. NIOSH skin notation profile: Parathion. By Hudson NL, Dotson GS. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2015-232.
  
  NIOSHTIC No 20046849
  
  f15_snp_2015-233.pdf
  
  
• Subjects:
  Occupational Health Safety
• Series:
  NIOSH Numbered Publications
• DOI:
  https://doi.org/10.26616/NIOSHPUB2015233
• Document Type:
  Text
• Genre:
  Report
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  8 numbered pages
• NIOSHTIC Number:
  nn:20046849
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:51f53e33dd2bf7c69c22c3b184bcdefae967c4c660b93191cea1c9355894977d506fb0e98593cc6021d223e3a4c8ac2bfc363392411503da9a7c4c7caa108fac
• Download URL:
  https://stacks.cdc.gov/view/cdc/36077/cdc_36077_DS1.pdf
• File Type:
  [PDF - 395.35 KB ]