Carriage of Streptococcus pneumoniae 3 Years after Start of Vaccination Program, the Netherlands

Spijkerman, Judith; van Gils, Elske J.M.; Veenhoven, Reinier H.; Hak, Eelko; Yzerman, F.; van der Ende, Arie; Wijmenga-Monsuur, Alienke J.; van den Dobbelsteen, Germie P.J.M.; Sanders, Elisabeth A.M.

doi:10.3201/eid1704.101115

i

Carriage of Streptococcus pneumoniae 3 Years after Start of Vaccination Program, the Netherlands

Supporting Files Public Domain

Apr 2011
By Spijkerman, Judith ; van Gils, Elske J.M. ; Veenhoven, Reinier H.
http://dx.doi.org/10.3201/eid1704.101115

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Alternative Title:

Emerg Infect Dis
Personal Author:

Spijkerman, Judith ; van Gils, Elske J.M. ; Veenhoven, Reinier H. ; Hak, Eelko ; Yzerman, F. ; van der Ende, Arie ; Wijmenga-Monsuur, Alienke J. ; van den Dobbelsteen, Germie P.J.M. ; Sanders, Elisabeth A.M.
Description:

To evaluate the effectiveness of the 7-valent pneumococcal conjugate vaccine (PCV7) program, we conducted a cross-sectional observational study on nasopharyngeal carriage of Streptococcus pneumoniae 3 years after implementation of the program in the Netherlands. We compared pneumococcal serotypes in 329 prebooster 11-month-old children, 330 fully vaccinated 24-month-old children, and 324 parents with age-matched pre-PCV7 (unvaccinated) controls (ages 12 and 24 months, n = 319 and n = 321, respectively) and 296 of their parents. PCV7 serotype prevalences before and after PCV7 implementation, respectively, were 38% and 8% among 11-month-old children, 36% and 4% among 24-month-old children, and 8% and 1% among parents. Non-PCV7 serotype prevalences were 29% and 39% among 11-month-old children, 30% and 45% among 24-month-old children, and 8% and 15% among parents, respectively; serotypes 11A and 19A were most frequently isolated. PCV7 serotypes were largely replaced by non-PCV7 serotypes. Disappearance of PCV7 serotypes in parents suggests strong transmission reduction through vaccination.
Subjects:
Source:

Emerg Infect Dis. 17(4):584-591.
Document Type:

Journal Article
Volume:

17
Issue:

4
Download URL:

https://stacks.cdc.gov/view/cdc/24310/cdc_24310_DS1.pdf
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[PDF - 260.92 KB]
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:cf2344da2c61946ce3e861938dd3b61b531dbe3a77a2653924bef939daf3a474

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