Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Cottell, Jennifer L. ; Webber, Mark A. ; Coldham, Nick G. ; Taylor, Dafydd L. ; Cerdeño-Tárraga, Anna M. ; ... More +
Cottell, Jennifer L. ; Webber, Mark A. ; Coldham, Nick G. ; Taylor, Dafydd L. ; Cerdeño-Tárraga, Anna M. ; Hauser, Heidi ; Thomson, Nicholas R. ; Woodward, Martin J. ; Piddock, Laura J.V. Less -
Description:
Antimicrobial drug resistance is a global challenge for the 21st century with the emergence of resistant bacterial strains worldwide. Transferable resistance to β-lactam antimicrobial drugs, mediated by production of extended-spectrum β-lactamases (ESBLs), is of particular concern. In 2004, an ESBL-carrying IncK plasmid (pCT) was isolated from cattle in the United Kingdom. The sequence was a 93,629-bp plasmid encoding a single antimicrobial drug resistance gene, blaCTX-M-14. From this information, PCRs identifying novel features of pCT were designed and applied to isolates from several countries, showing that the plasmid has disseminated worldwide in bacteria from humans and animals. Complete DNA sequences can be used as a platform to develop rapid epidemiologic tools to identify and trace the spread of plasmids in clinically relevant pathogens, thus facilitating a better understanding of their distribution and ability to transfer between bacteria of humans and animals.
Subjects:
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Animals Beta-Lactamases Cattle Gene Order Humans Molecular Epidemiology Molecular Sequence Data Phylogeny Plasmids
Source:
Emerg Infect Dis. 17(4):645-652.
Document Type:
Journal Article
Place as Subject:
Great Britain
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:bd201554d30154914e44ed1b96da04f9d5479fad6045caea8bb85ec70b8d552d
Download URL:
https://stacks.cdc.gov/view/cdc/24304/cdc_24304_DS1.pdf
File Type:

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