Chemical structure - transport rate relationships for model skin lipid membranes.

Details

• Personal Author:
  Guy RH ; Hall LL ; Hansch C ; Houk J
• Description:
  Model lipid membrane systems were studied in relation to chemical structure transport rate relationships applicable to the prediction of drug absorption through human skin. The model skin lipid transport system incorporated a rotating diffusion cell comprised of a donor compartment containing a solution of penetrant in water or aqueous buffer, a receptor compartment containing the same solution without penetrant, and a lipid membrane between the compartments made up of an organic liquid supported within a cellulose-ester filter with a pore size of 0.22 micrometers. The organic liquid membranes used were isopropyl-myristate (IPM) and tetradecane, and the penetrants tested included various esters of nicotinic-acid and phenol derivatives. A nonlinear quadratic relationship was determined for the logarithm of the experimental transport resistances and the logarithm of the octanol/water partition coefficients. The results were comparable to data obtained from the in-vitro transport of phenols through excised human cadaver skin. The authors conclude that the model skin lipid membranes mimic the in-vitro resistance of human skin and do not limit transport solely through simple diffusional resistance. [Description provided by NIOSH]
• Subjects:
  Dermatitis Drug Therapy Occupational Health Safety Skin Skin Absorption
• Keywords:
  NIOSH-Grant; Dermatitis; Skin-absorption; Simulation-methods; Analytical-models; Drug-therapy; Therapeutic-agents; Pharmacodynamics; Biokinetics
• ISSN:
  0737-402X
• Publisher:
  Mary Ann Liebert, Inc.
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; New York ; OSHA Region 2 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  341-352
• Volume:
  5
• NIOSHTIC Number:
  nn:00185576
• Citation:
  Altern Methods Toxicol 1987 Jan; 5:341-352
• Contact Point Address:
  Pharmacy University of California 926 Medical Sciences Building San Francisco, Calif 94143
• Editor(s):
  Goldberg AM
• Federal Fiscal Year:
  1987
• NORA Priority Area:
  Disease and Injury: Allergic and Irritant Dermatitis
• Performing Organization:
  University of California San Francisco, San Francisco, California
• Peer Reviewed:
  False
• Start Date:
  19840928
• Source Full Name:
  Alternative Methods in Toxicology, Vol. 5, In Vitro Toxicology - Approaches to Validation
• End Date:
  19871231
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/242735/cdc_242735_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]