Pharmacokinetics of ethoxyethanol in humans.

Details

• Personal Author:
  Berg R ; Hattis D
• Description:
  Pharmacokinetic models were developed of the uptake of ethoxyethanol (110805) (EE), metabolism of EE via ethoxyacetaldehyde to ethoxyacetic-acid (627032) (EAA), and urinary excretion of EAA. The performance of these models was tested with data on EE exposure, and preshift and postshift urinary EAA excretion/gram creatinine in a group of 36 painters studied over several successive days. Two models were constructed using only a single kinetically homogeneous body compartment for ethoxyacetaldehyde and EAA (the best estimate simplest model and the alternative simplest model). The other two models incorporated tissue compartments and diurnally varying blood flows adapted from earlier studies using perchloroethylene (the less simple model and the 70 hour model). From observations with other hydrophilic chemicals, tissue/blood partition coefficients were estimated. The less simple model resulted in a peak of urinary EAA just under 3 hours after the end of exposure and had a half time for urinary EAA excretion of 33 hours. About 42 percent of retained EE was metabolized via the aldehyde-dehydrogenase pathway. This method incorporated plausible features used in full physiologically based pharmacokinetic models, fit to the urinary EAA excretion data as well as any other and better than some models, demonstrated a later peak of EAA urinary excretion which is more in keeping with earlier studies, and performed slightly better in reconciling moles EE absorbed as calculated by other methods. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no PDF
• Subjects:
  Aldehydes Energy Metabolism Ethanol Formaldehyde Occupational Health Paint Safety Solvents Urine
• Keywords:
  Painting; Pharmacology; Solvents; Ethanols; Aldehydes; Humans; Kinetics; Urine-chemistry; Metabolic-study; NIOSH-Publication
• Document Type:
  Text
• Genre:
  Report
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-90
• NIOSHTIC Number:
  nn:00179876
• NTIS Accession Number:
  PB88221528
• Citation:
  Center for Technology, Policy and Industrial Development, Massachusetts Institute of Technology, Cambridge, Massachusetts, Report No. CTPID 88-1, 1988 Feb; :1-90
• CAS Registry Number:
  Ethoxyacetic acid (CAS RN 627-03-2) ; Glycol monoethyl ether (CAS RN 110-80-5)
• Federal Fiscal Year:
  1988
• Peer Reviewed:
  False
• Source Full Name:
  Center for Technology, Policy and Industrial Development, Massachusetts Institute of Technology, Cambridge, Massachusetts, Report No. CTPID 88-1, 90 pages, 91 references
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/242543/cdc_242543_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]