In Vivo Metabolism of the Cardiovascular Toxin, Allylamine

Details

• Personal Author:
  Ansari GAS ; Boor PJ ; Nelson TJ ; Sanduja R
• Description:
  Previous evidence from this laboratory demonstrated that allylamine, a known cardiovascular toxin, is metabolized in vitro to acrolein, which has been hypothesized to act as a distal toxin. In this study, 3-hydroxypropylmercapturic acid was isolated and identified by MS, NMR, and 2D-NMR spectroscopy as the sole urinary metabolite of allylamine metabolism in vivo. Parallel experiments showed reduced glutathione (GSH) depletion in several organs (most marked in aorta, blood, and lung), which is consistent with GSH conjugation of the proposed acrolein intermediate. These findings indicate that allylamine was metabolized in vivo to a highly reactive aldehyde which was converted to a mercapturic acid through a GSH conjugation pathway; the exact mechanisms of cellular damage remain unclear. [Description provided by NIOSH]
• Subjects:
  Aldehydes Biochemistry Energy Metabolism Formaldehyde Occupational Health Safety
• Keywords:
  Biochemical Effects Cellular Effects In Vivo Study Metabolism Toxic Effects
• ISSN:
  0006-2952
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  36
• Issue:
  24
• NIOSHTIC Number:
  nn:20060210
• Citation:
  Biochem Pharmacol 1987 Dec; 36(24):4347-4353
• Contact Point Address:
  Paul J. Boor, Chemical Pathology Division, Department of Pathology, University of Texas Medical Branch, Galveston, TX 77550, U.S.A.
• CAS Registry Number:
  Allylamine (CAS RN 107-11-9)
• Federal Fiscal Year:
  1988
• Performing Organization:
  University of Texas Medical Branch, Galveston, Texas
• Peer Reviewed:
  True
• Start Date:
  19860101
• Source Full Name:
  Biochemical Pharmacology
• End Date:
  19960630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:efdbe52643996741b005b415fd94c0b3b6fc9569a42ba7a978e48b1425065a030406e46ab8cce2608939dd1f651e1961c748c80afab8d5b13c992ba7182f4ee4
• Download URL:
  https://stacks.cdc.gov/view/cdc/224183/cdc_224183_DS1.pdf
• File Type:
  [PDF - 604.20 KB ]