Seroprevalence of Trichodysplasia Spinulosa–associated Polyomavirus

van der Meijden, Els; Kazem, Siamaque; Burgers, Manda M.; Janssens, Rene; Bavinck, Jan Nico Bouwes; de Melker, Hester; Feltkamp, Mariet C.W.

doi:10.3201/eid1708.110114

i

Seroprevalence of Trichodysplasia Spinulosa–associated Polyomavirus

Supporting Files Public Domain

Aug 2011
By van der Meijden, Els ; Kazem, Siamaque ; Burgers, Manda M. ; ...

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Alternative Title:

Emerg Infect Dis
Personal Author:

van der Meijden, Els ; Kazem, Siamaque ; Burgers, Manda M. ; Janssens, Rene ; Bavinck, Jan Nico Bouwes ; de Melker, Hester ; Feltkamp, Mariet C.W.
Description:

We identified a new polyomavirus in skin lesions from a patient with trichodysplasia spinulosa (TS). Apart from TS being an extremely rare disease, little is known of its epidemiology. On the basis of knowledge regarding other polyomaviruses, we anticipated that infections with trichodysplasia spinulosa-associated polyomavirus (TSV) occur frequently and become symptomatic only in immunocompromised patients. To investigate this hypothesis, we developed and used a Luminex-based TSV viral protein 1 immunoassay, excluded cross-reactivity with phylogenetically related Merkel cell polyomavirus, and measured TSV seroreactivity. Highest reactivity was found in a TS patient. In 528 healthy persons in the Netherlands, a wide range of seroreactivities was measured and resulted in an overall TSV seroprevalence of 70% (range 10% in small children to 80% in adults). In 80 renal transplant patients, seroprevalence was 89%. Infection with the new TSV polyomavirus is common and occurs primarily at a young age.
Subjects:

Adolescent Adult Aged Antibodies, Viral Capsid Proteins Child Child, Preschool Epidemiology Humans Immunoassay Immunocompromised Host Infant Kidney Transplantation Middle Aged Netherlands Polyomavirus Polyomavirus Infections Research Seroepidemiologic Studies Seroprevalence Skin Diseases The Netherlands Trichodysplasia Spinulosa Tumor Virus Infections Viruses Young Adult
Source:

Emerg Infect Dis. 17(8):1355-1363.
Document Type:

Journal Article
Volume:

17
Issue:

8
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:24d4c0535815c6eb9a4c4eaf843599be1b05933fbe4b00a1b594e8bfc101f438
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https://stacks.cdc.gov/view/cdc/24220/cdc_24220_DS1.pdf
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[PDF - 787.87 KB ]

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