Asymptomatic Primary Merkel Cell Polyomavirus Infection among Adults

Tolstov, Yanis L.; Knauer, Alycia; Chen, Jian Guo; Kensler, Thomas W.; Kingsley, Lawrence A.; Moore, Patrick S.; Chang, Yuan

doi:10.3201/eid1708.110079

i

Asymptomatic Primary Merkel Cell Polyomavirus Infection among Adults

Supporting Files

Aug 2011
By Tolstov, Yanis L. ; Knauer, Alycia ; Chen, Jian Guo ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Tolstov, Yanis L. ; Knauer, Alycia ; Chen, Jian Guo ; Kensler, Thomas W. ; Kingsley, Lawrence A. ; Moore, Patrick S. ; Chang, Yuan
Description:

Merkel cell polyomavirus (MCV) is a recently discovered virus that causes 80% of Merkel cell carcinomas. We examined data for 564 gay/bisexual male participants >18 years of age in the Multicenter AIDS Cohort Study in Pittsburgh, Pennsylvania, USA, and found that 447 (79.3%) were MCV-antibody positive at initial enrollment. Of the 117 MCV-seronegative men, 31 subsequently seroconverted over a 4-year follow-up period, corresponding to a 6.6% annual conversion rate. MCV immunoglobulin G levels remained detectable up to 25 years after exposure. No signs, symptoms, or routine diagnostic test results were associated with MCV infection, and no correlation between HIV infection or AIDS progression and MCV infection was noted. An initial correlation between chronic hepatitis B virus infection and MCV prevalence could not be confirmed among MCV seroconverters or in studies of a second hepatitis B virus-hyperendemic cohort from Qidong, China. In adults, MCV is typically an asymptomatic, common, and commensal viral infection that initiates rare cancers after virus (rather than host cell) mutations.
Subjects:

Adult Antibodies, Viral Bisexuality Carcinoma, Merkel Cell Cohort Studies Homosexuality, Male Humans Male Middle Aged Polyomavirus Infections Research Skin Neoplasms Tumor Virus Infections
Source:

Emerg Infect Dis. 17(8):1371-1380.
Document Type:

Journal Article
Funding:

CA120726/CA/NCI NIH HHS/United States ; UO1-AI-35041/AI/NIAID NIH HHS/United States
Place as Subject:

Pittsburgh, PA
Location:

North America
Volume:

17
Issue:

8
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:529998b072cb41dcf74af92c5af46be407936f4c2d3686cb71c7a96a16202c26
Download URL:

https://stacks.cdc.gov/view/cdc/24219/cdc_24219_DS1.pdf
File Type:

[PDF - 535.19 KB ]

File Language:

English

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