Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Toracchio, Sonia ; Foyle, Annette ; Sroller, Vojtech ; Reed, Jon A. ; Wu, Jun ; ... More +
Toracchio, Sonia ; Foyle, Annette ; Sroller, Vojtech ; Reed, Jon A. ; Wu, Jun ; Kozinetz, Claudia A. ; Butel, Janet S. Less -
Description:
To test the hypothesis that Merkel cell polyomavirus (MCPyV) can infect cells of the lymphoid system, we analyzed 353 specimens, including 152 non-Hodgkin lymphomas, 44 Hodgkin lymphomas, 110 benign lymph nodes, 27 lymph nodes with metastasis, and 20 extranodal tissue samples. MCPyV DNA was detected by quantitative PCR in 13 (6.6%) of 196 lymphomas, including 5 (20.8%) of 24 chronic lymphocytic leukemia specimens, and in 11 (10%) of 110 benign lymph nodes, including 8 (13.1%) of 61 samples of reactive hyperplasia and 3 (10.3%) of 29 normal lymph nodes. Other samples were MCPyV negative. Sequence analysis of 9 virus-positive samples confirmed the identity of MCPyV; 3 viral strains were represented. Immunohistochemical testing showed that 1 T-cell lymphoma expressed MCPyV T-antigen. These findings suggest that the lymphoid system plays a role in MCPyV infection and may be a site for MCPyV persistence.
Subject:
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Adolescent
Adult
Aged
Aged, 80 And Over
Carcinoma, Merkel Cell
DNA, Viral
Female
Humans
Lymph Nodes
Male
Middle Aged
Polyomavirus
Polyomavirus Infections
Tumor Virus Infections
Young Adult

Source:
Emerg Infect Dis. 16(11):1702-1709.
Document Type:
Journal Article
Place as Subject:
Nova Scotia. Canada
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:95cdd6168b1e9faac8a8a0802d0ab4f57ca39814e0ad6bb1bf8652583f42a103
File Type:

Supporting Files

• 	10-0628-F.gif	gif
  	10-0628-F.jpg	jpeg
  	10-0628_finalR.nxml	txt
  	license.txt	txt

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