Lymphotropism of Merkel Cell Polyomavirus Infection, Nova Scotia, Canada

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Toracchio, Sonia ; Foyle, Annette ; Sroller, Vojtech ; Reed, Jon A. ; Wu, Jun ; Kozinetz, Claudia A. ; Butel, Janet S.
• Description:
  To test the hypothesis that Merkel cell polyomavirus (MCPyV) can infect cells of the lymphoid system, we analyzed 353 specimens, including 152 non-Hodgkin lymphomas, 44 Hodgkin lymphomas, 110 benign lymph nodes, 27 lymph nodes with metastasis, and 20 extranodal tissue samples. MCPyV DNA was detected by quantitative PCR in 13 (6.6%) of 196 lymphomas, including 5 (20.8%) of 24 chronic lymphocytic leukemia specimens, and in 11 (10%) of 110 benign lymph nodes, including 8 (13.1%) of 61 samples of reactive hyperplasia and 3 (10.3%) of 29 normal lymph nodes. Other samples were MCPyV negative. Sequence analysis of 9 virus-positive samples confirmed the identity of MCPyV; 3 viral strains were represented. Immunohistochemical testing showed that 1 T-cell lymphoma expressed MCPyV T-antigen. These findings suggest that the lymphoid system plays a role in MCPyV infection and may be a site for MCPyV persistence.
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Carcinoma, Merkel Cell Dna, Viral Female Humans Lymph Nodes Male Middle Aged Polyomavirus Polyomavirus Infections Tumor Virus Infections Young Adult

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• Source:
  Emerg Infect Dis. 16(11):1702-1709.
• Document Type:
  Journal Article
• Place as Subject:
  Nova Scotia. Canada
• Location:
  North America
• Volume:
  16
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:95cdd6168b1e9faac8a8a0802d0ab4f57ca39814e0ad6bb1bf8652583f42a103
• Download URL:
  https://stacks.cdc.gov/view/cdc/18339/cdc_18339_DS1.pdf
• File Type:
  [PDF - 358.87 KB ]