Observations concerning alveolar dust clearance.

Details

• Personal Author:
  Ferin J
• Description:
  Experiments with rats exposed to titanium-dioxide (7440326) dust reveal that the onset of alveolar clearance is immediate in terms of minutes, overlapping in time with the rapid clearance of particles from the tracheobronchial tree. Two days after the onset of exposure the number of alveolar macrophages is significantly increased. In 88 days (half time), 50 percent of the initial lung burden is cleared. Multiple exposures may change the clearance rate. Clearance efficiency may improve by experimental means. Lung clearance of titanium-dioxide in animals subjected to preliminary exposure to sulfur-dioxide (7446095) is significantly depressed. [Description provided by NIOSH]
• Subjects:
  Dust Hazardous Substances Occupational Health Respiratory System Safety
• Keywords:
  NIOSH-Grant; Respiratory-functions; Lung-clearance; Respiratory-mechanics; Inorganic-gases; Toxic-gases; Dust-inhalation; Lung-dust-burden
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Proceedings
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-18
• NIOSHTIC Number:
  nn:00008980
• Citation:
  Department of Radiation Biology and Biophysics, School of Medicine and Dentistry (Unpublished; Presented at the International Conference on Coal Workers' Pneumoconiosis, New York, September 13-17, 1971), Rochester, New York, 1971 Sep; :1-18
• Contact Point Address:
  Radiation Biology & Biophysics University of Rochester Dept of Radiation Bio & Biophy Rochester, N Y 14620
• CAS Registry Number:
  Sulfur dioxide (CAS RN 7446-09-5) ; Titanium (CAS RN 7440-32-6)
• Federal Fiscal Year:
  1971
• Performing Organization:
  University of Rochester, Rochester, New York
• Peer Reviewed:
  False
• Start Date:
  19700901
• Source Full Name:
  Department of Radiation Biology and Biophysics, School of Medicine and Dentistry (Unpublished; Presented at the International Conference on Coal Workers' Pneumoconiosis, New York, September 13-17, 1971), Rochester, New York, 18 pages, 26 references
• End Date:
  19791130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/241683/cdc_241683_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]