Observations concerning alveolar dust clearance

Details

• Personal Author:
  Ferin J
• Description:
  Experiments with rats exposed to titanium-dioxide (7440326) dust reveal that the onset of alveolar clearance is immediate in terms of minutes, overlapping in time with the rapid clearance of particles from the tracheobronchial tree. Two days after the onset of exposure the number of alveolar macrophages is significantly increased. In 88 days (half time), 50 percent of the initial lung burden is cleared. Multiple exposures may change the clearance rate. Clearance efficiency may improve by experimental means. Lung clearance of titanium-dioxide in animals subjected to preliminary exposure to sulfur-dioxide (7446095) is significantly depressed. [Description provided by NIOSH]
• Subjects:
  Dust Hazardous Substances Occupational Health Respiratory System Safety
• Keywords:
  Dust-inhalation Inorganic-gases Lung-clearance Lung-dust-burden NIOSH-Grant Respiratory-functions Respiratory-mechanics Toxic-gases
• ISSN:
  0077-8923
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  66-72
• Volume:
  200
• Issue:
  1
• NIOSHTIC Number:
  nn:20038841
• Citation:
  Ann NY Acad Sci 1972 Dec; 200(1):66-72
• CAS Registry Number:
  Sulfur dioxide (CAS RN 7446-09-5) ; Titanium (CAS RN 7440-32-6)
• Federal Fiscal Year:
  1973
• Performing Organization:
  University of Rochester, Rochester, New York
• Peer Reviewed:
  True
• Start Date:
  19700901
• Source Full Name:
  Annals of the New York Academy of Sciences
• End Date:
  19791130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cb6eaa30f6541c09425575bdd6294496241b602ea6d57eb335b71ac183f82819e696b5c5c230d162c7ee30e8ef763193659464d74d301d80b358376eed80da5e
• Download URL:
  https://stacks.cdc.gov/view/cdc/192396/cdc_192396_DS1.pdf
• File Type:
  [PDF - 380.17 KB ]