Effect of dietary intake of lead acetate on copper metabolism in male rats.

Details

• Personal Author:
  Klauder DS ; Murthy L ; Petering HG
• Description:
  The effect of lead (7439921) on copper (7440508) metabolism was investigated. Male Sprague-Dawley-rats were fed diets ranging in copper content from 0.5 to 2.5 micrograms per day. Fifty percent of the animals also received a diet containing 0.5 percent lead. During the 8 week experimental period, food and water intakes were periodically monitored and blood and urine samples were collected. Lead treated animals had growth retardation. There were negligible differences in food and water intakes. Lead inhibition was inversely related to dietary copper amounts. Lead treated animals had 15 to 20 times more lead in the urine than controls. Ceruloplasmin concentrations, a reliable measurement of copper metabolism, in lead exposed animals were markedly lower compared to controls. Erythrocyte lead concentrations decreased as the dietary copper increased. The authors conclude that one of the toxic effects of lead is to adversely change copper metabolism. [Description provided by NIOSH]
• Subjects:
  Energy Metabolism Growth Laboratories Lead Metals, Heavy Occupational Health Safety Toxicology
• Keywords:
  NIOSH-Publication; NIOSH-Grant; Stokinger; Toxicology; Heavy-metals; Metabolism; Laboratory-animals; Lead-compounds; Growth-factors
• ISSN:
  0361-5162
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  131-136
• Volume:
  6
• NIOSHTIC Number:
  nn:00113660
• Citation:
  Trace Subst Environ Health 1973 Jan; 6:131-136
• Contact Point Address:
  Environmental Health Kettering Laboratory Eden & Bethesda Avenues Cincinnati, Ohio 45219
• CAS Registry Number:
  Copper (CAS RN 7440-50-8) ; Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  1973
• Performing Organization:
  University of Cincinnati, Cincinnati, Ohio
• Peer Reviewed:
  True
• Start Date:
  19700901
• Source Full Name:
  Trace Substances in Environmental Health
• End Date:
  19790831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/241273/cdc_241273_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]