Prenatal lead exposure and bone growth.

Details

• Personal Author:
  Hamilton JD ; O'Flaherty EJ
• Description:
  An experimental system of lead (7439921) related prenatal and postnatal growth retardation in rats was developed. Sprague-Dawley- rats and Long-Evans-rats were used in these studies. Rats were exposed to lead in their drinking water at up to 1000 parts per million. A significant effect on fetal bone mineralization could not be excluded and there was a definite effect on fetal body weight following maternal lead exposure. Reduced food intake during the first week of lead exposure was the primary determinant of reduced body and skeletal growth in the lead exposed weanling female rats. When maternal lead exposure was continued during lactation a greater degree of lead related growth retardation in rat offspring occurred than when maternal lead exposure was terminated at parturition. Combined prenatal and postnatal lead exposure impaired bone resorption and increased growth plate widths. In studies using matrix induced endochondral bone plaques, locally applied lead enhanced plaque mineralization through comineralization of lead with calcium. When lead was administered in drinking water, plaque mineralization was also enhanced through the comineralization of lead with calcium. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no pdf
• Subjects:
  Growth Laboratories Lead Lead Poisoning Metals, Heavy Occupational Health Safety Urogenital Diseases Urogenital System
• Keywords:
  NIOSH-Grant; Reproductive-system-disorders; Reproductive-hazards; Laboratory-animals; Lead-poisoning; Growth-inhibition; Transplacental-exposure; Heavy-metals
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-118
• NIOSHTIC Number:
  nn:00203285
• NTIS Accession Number:
  PB92136258
• Citation:
  Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 1990 Jul; :1-118
• Contact Point Address:
  Environmental Health University of Cincinnati 3223 Eden Avenue Cincinnati, OH 45267
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  1990
• NORA Priority Area:
  Reproductive System Disorders
• Performing Organization:
  University of Cincinnati, Cincinnati, Ohio
• Peer Reviewed:
  False
• Start Date:
  19870501
• Source Full Name:
  Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio
• End Date:
  19900430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246240/cdc_246240_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]