An evaluation of in vitro testing for mutagens.

Details

• Personal Author:
  Legator MS ; Rinkus SJ ; Legator MS ; Rinkus SJ
• Description:
  The use of in-vigro tests for detecting chemical mutagenicity is evaluated. Types of aberrations produced in cell culture systems are discussed, including DNA alkylation, arylation and acylation. Mutations arising from antireplication effects are considered. The influence of metabolic activation is reviewed and specific sites of action are described. Structure activity relationships and correlations between carcinogenicity and mutagenicity in Salmonella tests are discussed. The authors conclude that eukaryotic organisms should be tested in both in-vitro and in-vivo systems before mutagenicity hazards can be evaluated. [Description provided by NIOSH]
• Subjects:
  Acids, Acyclic DNA Energy Metabolism Genetics Neoplasms Occupational Health Safety
• Keywords:
  Genetics; In-vitro-study; Deoxyribonucleic-acids; Acyclic-compounds; Metabolism; Cancer; Bioassays;
• Document Type:
  Text
• Genre:
  Proceedings ; Proceedings
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  117-133
• NIOSHTIC Number:
  nn:00105773
• Citation:
  NIOSH 1980 Oct; :117-133
• Federal Fiscal Year:
  1981
• Peer Reviewed:
  False
• Source Full Name:
  Proceedings of a Workshop on Methodology for Assessing Reproductive Hazards in the Workplace, April 19-22, 1978, P.F. Infante and M.S. Legator, Eds. Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, U.S. Department of Health and Human Services
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/241149/cdc_241149_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]