Axonal specification of Schwann cell expression and myelination.

Details

• Personal Author:
  Spencer PS
• Description:
  A unitary theory of neuronal regulation of Schwann cell function which attempts to correlate contemporary theories of cell sorting, interaction, and metabolic regulation is proposed by the authors. The theory is based on the assumptions that Schwann cells form a single undifferentiated population in the fetal nerve; that complementary molecular sites exist on the axolemma and enable the Schwann cell to adhere to the axon, provide contact inhibition, and produce myelin; and that during fetal development the axolemma of axons to be myelinated progresses from an undifferentiated to a differentiated state. Several phases of the myelination process are discussed and related to initial and terminal regions of myelinated fibers, and to the central and peripheral nervous system transitional region. Instances of nonaxonal myelination are mentioned. The proposed theory is used to explain reactive and pathological states based on axon and Schwann cell relationships. Methods used to prepare Schwann cells for investigation are included. The authors conclude that peripheral nerves provide the ideal site to study neuronal regulation because of their simple organization and accessibility, and that the elucidation of cellular relationships in this area may prove relevant to those present in the brain. [Description provided by NIOSH]
• Subjects:
  Biochemistry Cytology Energy Metabolism Laboratories Nervous System Occupational Health Safety
• Keywords:
  NIOSH-Grant; Neurotoxic-effects; Membrane-dysfunction; Nerve-fibers; Metabolism; Biochemical-reactions; Nuclear-membrane; Physiological-function; Peripheral-nervous-system; Synergism; Cellular-function; Cytological-analysis; Research-laboratories
• ISBN:
  9780890042151
• Publisher:
  Raven Press
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Book
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  389-405
• NIOSHTIC Number:
  nn:00091811
• Citation:
  Physiology and Pathobiology of Axons. Waxman-SG, ed., New York: Raven Press, 1978 Jan; :389-405
• Contact Point Address:
  Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
• Editor(s):
  Waxman SG
• Federal Fiscal Year:
  1978
• NORA Priority Area:
  Neurotoxic Effects
• Performing Organization:
  Yeshiva University, New York, New York
• Peer Reviewed:
  False
• Start Date:
  19751101
• Source Full Name:
  Physiology and Pathobiology of Axons
• End Date:
  19850331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/240923/cdc_240923_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]