Deaths Attributable to Carbapenem-Resistant Enterobacteriaceae Infections

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Falagas, Matthew E. ; Tansarli, Giannoula S. ; Karageorgopoulos, Drosos E. ; Vardakas, Konstantinos Z.
• Description:
  We evaluated the number of deaths attributable to carbapenem-resistant Enterobacteriaceae by using studies from around the world published before April 9, 2012. Attributable death was defined as the difference in all-cause deaths between patients with carbapenem-resistant infections and those with carbapenem-susceptible infections. Online databases were searched, and data were qualitatively synthesized and pooled in a metaanalysis. Nine studies met inclusion criteria: 6 retrospective case-control studies, 2 retrospective cohort studies, and 1 prospective cohort study. Klebsiella pneumoniae was the causative pathogen in 8 studies; bacteremia was the only infection in 5 studies. We calculated that 26%-44% of deaths in 7 studies were attributable to carbapenem resistance, and in 2 studies, which included bacteremia and other infections, -3% and -4% of deaths were attributable to carbapenem resistance. Pooled outcomes showed that the number of deaths was significantly higher in patients with carbapenem-resistant infections and that the number of deaths attributable to carbapenem resistance is considerable.
• Subjects:
  Anti-Bacterial Agents Bacteremia Carbapenems Case-Control Studies Drug Resistance, Bacterial Enterobacteriaceae Enterobacteriaceae Infections Humans Klebsiella Infections Klebsiella Pneumoniae Prospective Studies Retrospective Studies

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• Source:
  Emerg Infect Dis. 20(7):1170-1175.
• Document Type:
  Journal Article
• Volume:
  20
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:22c9e92ae30ff4c608be081954f76a6ec2a6533c5415bdea8253971770367b21
• Download URL:
  https://stacks.cdc.gov/view/cdc/24088/cdc_24088_DS1.pdf
• File Type:
  [PDF - 408.58 KB ]