Electromotive interactions of metals in asbestos carcinogenicity.

Details

• Personal Author:
  Sunderman FW Jr.
• Description:
  An investigation into the carcinogenicity of metallic dusts, manganese (7439965) (Mn), chromium (7440473) (Cr), aluminum (7429905) (Al), nickel-sulfide (1344496) (NiS), nickel-carbonyl (13463393), and iron carbonyl-(13463406) was performed. Intrarenal (i.r.) injection of nickel-subsulfate (7786814) (Ni3S2) was found to induce erythrocytosis in Fischer-rats. A single i.r. injection at 5 dosage levels from 0.6 to 10mg/rat caused erythrocytosis to develop reaching a maximum at 2 to 3 months. Blood erythrocyte counts returned to normal by 7 months. No significant changes occurred in leukocyte or platelet counts. Marked erythroid hyperplasia was present in bone marrow of rats that received i.r. Ni3S2, but not in controls or in rats that received i.m. Ni3S2. This study establishes the time response and dose response relationships for Ni3S2 induction of erythrocytosis in rats. Studies into the effects of Mn on tumorigenesis of Ni3S2 indicate that concurrent administration of Mn did not affect the local retention of Ni derived from Ni3S2. This study is consistent with the hypothesis that Mn may antagonize Ni (7440020) inhibition of RNA polymerase activity in rhabdomyocytes. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no PDF
• Subjects:
  Animals Carcinogens Hematologic Diseases Metals Metals, Heavy Nickel Occupational Health Particulate Matter Safety
• Keywords:
  NIOSH-Contract; Contract-099-72-0024; Transition-metals; Nickel-compounds; Heavy-metals; Particulates; Carcinogenesis; Blood-disorders; Animal-models; Experimental-methods
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  Connecticut ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-44
• NIOSHTIC Number:
  nn:00080944
• NTIS Accession Number:
  PB82152943
• Citation:
  University of Connecticut School of Medicine, Farmington, Connecticut 1975 Oct; :1-44
• CAS Registry Number:
  Aluminum (CAS RN 7429-90-5) ; Chromium (CAS RN 7440-47-3) ; Iron pentacarbonyl (CAS RN 13463-40-6) ; Manganese (CAS RN 7439-96-5) ; Nickel (CAS RN 7440-02-0) ; Nickel sulfate (NiSO4) (CAS RN 7786-81-4) ; Nickel sulfide (NiS) (CAS RN Nickel sulfide (NiS) (CAS RN 16812-54-7)) ; Nickel tetracarbonyl (CAS RN 13463-39-3)
• Federal Fiscal Year:
  1976
• Performing Organization:
  University of Connecticut School of Medicine
• Peer Reviewed:
  False
• Source Full Name:
  University of Connecticut School of Medicine, Farmington, Connecticut
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/240807/cdc_240807_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]