Lineage-specific Virulence Determinants of Haemophilus influenzae Biogroup aegyptius

Strouts, Fiona R.; Power, Peter; Croucher, Nicholas J.; Corton, Nicola; van Tonder, Andries; Quail, Michael A.; Langford, Paul R.; Hudson, Michael J.; Parkhill, Julian; Kroll, J. Simon; Bentley, Stephen D.

doi:10.3201/eid1803.110728

i

Lineage-specific Virulence Determinants of Haemophilus influenzae Biogroup aegyptius

Supporting Files

Mar 2012
By Strouts, Fiona R. ; Power, Peter ; Croucher, Nicholas J. ; ...

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Alternative Title:

Emerg Infect Dis
Personal Author:

Strouts, Fiona R. ; Power, Peter ; Croucher, Nicholas J. ; Corton, Nicola ; van Tonder, Andries ; Quail, Michael A. ; Langford, Paul R. ; Hudson, Michael J. ; Parkhill, Julian ; Kroll, J. Simon ; Bentley, Stephen D.
Description:

An emergent clone of Haemophilus influenzae biogroup aegyptius (Hae) is responsible for outbreaks of Brazilian purpuric fever (BPF). First recorded in Brazil in 1984, the so-called BPF clone of Hae caused a fulminant disease that started with conjunctivitis but developed into septicemic shock; mortality rates were as high as 70%. To identify virulence determinants, we conducted a pan-genomic analysis. Sequencing of the genomes of the BPF clone strain F3031 and a noninvasive conjunctivitis strain, F3047, and comparison of these sequences with 5 other complete H. influenzae genomes showed that >77% of the F3031 genome is shared among all H. influenzae strains. Delineation of the Hae accessory genome enabled characterization of 163 predicted protein-coding genes; identified differences in established autotransporter adhesins; and revealed a suite of novel adhesins unique to Hae, including novel trimeric autotransporter adhesins and 4 new fimbrial operons. These novel adhesins might play a critical role in host-pathogen interactions.
Subjects:

Adhesin Adhesins, Bacterial Bacteria BPF Brazilian Purpuric Fever Gene Order Genome, Bacterial Haemophilus Aegyptius Haemophilus Infections Haemophilus Influenzae Host-Pathogen Interactions Humans Molecular Sequence Annotation Molecular Sequence Data Operon Pathogenicity Phylogeny Research Sepsis Sequence Homology Trimeric Autotransporter Trimeric Autotransporter Adhesins Virulence Virulence Factors
Source:

Emerg Infect Dis. 18(3):449-457.
Document Type:

Journal Article
Funding:

Wellcome Trust/United Kingdom
Volume:

18
Issue:

3
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:3fd953c55dcc017f71fccf3f78ed416447b946202dcae47579df896d9989261c
Download URL:

https://stacks.cdc.gov/view/cdc/23815/cdc_23815_DS1.pdf
File Type:

[PDF - 316.89 KB ]

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