Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1803.110728
Personal Author:
Strouts, Fiona R. ; Power, Peter ; Croucher, Nicholas J. ; Corton, Nicola ; van Tonder, Andries ; ... More +
Strouts, Fiona R. ; Power, Peter ; Croucher, Nicholas J. ; Corton, Nicola ; van Tonder, Andries ; Quail, Michael A. ; Langford, Paul R. ; Hudson, Michael J. ; Parkhill, Julian ; Kroll, J. Simon ; Bentley, Stephen D. Less -
Description:
An emergent clone of Haemophilus influenzae biogroup aegyptius (Hae) is responsible for outbreaks of Brazilian purpuric fever (BPF). First recorded in Brazil in 1984, the so-called BPF clone of Hae caused a fulminant disease that started with conjunctivitis but developed into septicemic shock; mortality rates were as high as 70%. To identify virulence determinants, we conducted a pan-genomic analysis. Sequencing of the genomes of the BPF clone strain F3031 and a noninvasive conjunctivitis strain, F3047, and comparison of these sequences with 5 other complete H. influenzae genomes showed that >77% of the F3031 genome is shared among all H. influenzae strains. Delineation of the Hae accessory genome enabled characterization of 163 predicted protein-coding genes; identified differences in established autotransporter adhesins; and revealed a suite of novel adhesins unique to Hae, including novel trimeric autotransporter adhesins and 4 new fimbrial operons. These novel adhesins might play a critical role in host-pathogen interactions.
Subject:
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Adhesin
Adhesins, Bacterial
Bacteria
BPF
Brazilian Purpuric Fever
Gene Order
Genome, Bacterial
Haemophilus Aegyptius
Haemophilus Infections
Haemophilus Influenzae
Haemophilus Influenzae Biogroup Aegyptius
Host-Pathogen Interactions
Humans
Molecular Sequence Annotation
Molecular Sequence Data
Operon
Pathogenicity
Phylogeny
Research
Sepsis
Sequence Homology
Trimeric Autotransporter
Trimeric Autotransporter Adhesins
Virulence
Virulence Factors
Virulence

Source:
Emerg Infect Dis. 18(3):449-457.
Document Type:
Journal Article
Funding:
Wellcome Trust/United Kingdom
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:3fd953c55dcc017f71fccf3f78ed416447b946202dcae47579df896d9989261c
File Type:

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