A Pilot Study of Host Genetic Variants Associated with Influenza-associated Deaths among Children and Young Adults1

Ferdinands, Jill M.; Denison, Amy M.; Dowling, Nicole F.; Jost, Heather A.; Gwinn, Marta L.; Liu, Lindy; Zaki, Sherif R.; Shay, David K.

doi:10.3201/eid1712.111002

i

A Pilot Study of Host Genetic Variants Associated with Influenza-associated Deaths among Children and Young Adults1

Supporting Files Public Domain

Dec 2011
By Ferdinands, Jill M. ; Denison, Amy M. ; Dowling, Nicole F. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Ferdinands, Jill M. ; Denison, Amy M. ; Dowling, Nicole F. ; Jost, Heather A. ; Gwinn, Marta L. ; Liu, Lindy ; Zaki, Sherif R. ; Shay, David K.
Description:

We compared the prevalence of 8 polymorphisms in the tumor necrosis factor and mannose-binding lectin genes among 105 children and young adults with fatal influenza with US population estimates and determined in subanalyses whether these polymorphisms were associated with sudden death and bacterial co-infection among persons with fatal influenza. No differences were observed in genotype prevalence or minor allele frequencies between persons with fatal influenza and the reference sample. Fatal cases with low-producing MBL2 genotypes had a 7-fold increased risk for invasive methicillin-resistant Staphylococcus aureus (MRSA) co-infection compared with fatal cases with high- and intermediate-producing MBL2 genotypes (odds ratio 7.1, 95% confidence interval 1.6-32.1). Limited analysis of 2 genes important to the innate immune response found no association between genetic variants and fatal influenza infection. Among children and young adults who died of influenza, low-producing MBL2 genotypes may have increased risk for MRSA co-infection.
Subjects:

Adolescent Adult Child Child, Preschool Coinfection Female Gene Frequency Genetic Variation Host-Pathogen Interactions Humans Infant Infant, Newborn Influenza, Human Male Mannose-Binding Lectin Pilot Projects Polymorphism, Single Nucleotide Research Risk Factors Staphylococcal Infections Tumor Necrosis Factor-alpha Young Adult
Source:

Emerg Infect Dis. 17(12):2294-2302.
Document Type:

Journal Article
Place as Subject:

United States
Location:

North America
Volume:

17
Issue:

12
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:a6706db9fa6fbe3b12626da5c7d9129862bc5bcd26b5fbb8a8c31fa19ba60552
Download URL:

https://stacks.cdc.gov/view/cdc/23798/cdc_23798_DS1.pdf
File Type:

[PDF - 210.38 KB ]

File Language:

English

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