Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1712.111002
Personal Author:
Ferdinands, Jill M. ; Denison, Amy M. ; Dowling, Nicole F. ; Jost, Heather A. ; Gwinn, Marta L. ; ... More +
Ferdinands, Jill M. ; Denison, Amy M. ; Dowling, Nicole F. ; Jost, Heather A. ; Gwinn, Marta L. ; Liu, Lindy ; Zaki, Sherif R. ; Shay, David K. ; Less -
Description:
We compared the prevalence of 8 polymorphisms in the tumor necrosis factor and mannose-binding lectin genes among 105 children and young adults with fatal influenza with US population estimates and determined in subanalyses whether these polymorphisms were associated with sudden death and bacterial co-infection among persons with fatal influenza. No differences were observed in genotype prevalence or minor allele frequencies between persons with fatal influenza and the reference sample. Fatal cases with low-producing MBL2 genotypes had a 7-fold increased risk for invasive methicillin-resistant Staphylococcus aureus (MRSA) co-infection compared with fatal cases with high- and intermediate-producing MBL2 genotypes (odds ratio 7.1, 95% confidence interval 1.6-32.1). Limited analysis of 2 genes important to the innate immune response found no association between genetic variants and fatal influenza infection. Among children and young adults who died of influenza, low-producing MBL2 genotypes may have increased risk for MRSA co-infection.
Subject:
[+]
Adolescent
Adult
Child
Child, Preschool
Coinfection
Female
Gene Frequency
Genetic Variation
Host-Pathogen Interactions
Humans
Infant
Infant, Newborn
Influenza, Human
Male
Mannose-Binding Lectin
Methicillin-Resistant Staphylococcus Aureus
Pilot Projects
Polymorphism, Single Nucleotide
Research
Risk Factors
Staphylococcal Infections
Tumor Necrosis Factor-alpha
Young Adult

Source:
Emerg Infect Dis. 17(12):2294-2302. ;
Document Type:
Journal Article ;
Place as Subject:
United States ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:a6706db9fa6fbe3b12626da5c7d9129862bc5bcd26b5fbb8a8c31fa19ba60552
File Type:

Supporting Files

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  	11-1002_finalR.nxml	txt
  	license.txt	txt

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