Enterovirus Co-infections and Onychomadesis after Hand, Foot, and Mouth Disease, Spain, 2008

Bracho, Maria A.; González-Candelas, Fernando; Valero, Ana; Córdoba, Juan; Salazar, Antonio

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Enterovirus Co-infections and Onychomadesis after Hand, Foot, and Mouth Disease, Spain, 2008

Supporting Files Public Domain

Dec 2011
By Bracho, Maria A. ; González-Candelas, Fernando ; Valero, Ana ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Bracho, Maria A. ; González-Candelas, Fernando ; Valero, Ana ; Córdoba, Juan ; Salazar, Antonio
Description:

Hand, foot, and mouth disease (HFMD), a common disease caused by enteroviruses (EVs), usually affects children. Clustered and sporadic HFMD cases, followed by onychomadesis (nail shedding), occurred during summer and fall 2008 in Valencia, Spain. Fecal samples from onychomadesis patients, who did or did not have previous HFMD, and from healthy children exposed to onychomadesis patients tested positive for EV. The complete viral protein 1 capsid gene sequence was obtained for typing and phylogenetic analysis. Two EV serotypes, coxsackievirus A10 and coxsackievirus B1 (CVB1), were mainly detected as a monoinfection or co-infection in a childcare center where an onychomadesis outbreak occurred. On the basis of our results, and detection of CVB1 in 2 other contemporary onychomadesis outbreaks in childcare centers in Spain, we propose that mixed infection of an EV serotype that causes HFMD, plus the serotype CVB1, could explain the emergence after HFMD of onychomadesis, a rare and late complication.
Subjects:

And Mouth Disease Base Sequence Case-Control Studies Child, Preschool Co-Infection Communicable Diseases, Emerging Complications DNA, Viral Enterovirus Enterovirus A, Human Enterovirus B, Human Enterovirus Infections Female Foot Hand Hand, Foot And Mouth Disease Hfmd Humans Infant Male Nail Diseases Nail Shedding Onychomadesis Phylogeny Research Serotyping Spain Viruses
Source:

Emerg Infect Dis. 17(12):2223-2231.
Document Type:

Journal Article
Volume:

17
Issue:

12
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:9ebc974a02a4010667207302abb8f3d5c45111c1acd746fc2c2975100542e517
Download URL:

https://stacks.cdc.gov/view/cdc/23771/cdc_23771_DS1.pdf
File Type:

[PDF - 359.85 KB ]

File Language:

English

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