Leptospirosis as Frequent Cause of Acute Febrile Illness in Southern Sri Lanka

Reller, Megan E.; Bodinayake, Champika; Nagahawatte, Ajith; Devasiri, Vasantha; Kodikara-Arachichi, Wasantha; Strouse, John J.; Flom, Judith E.; Dumler, J. Stephen; Woods, Christopher W.

doi:10.3201/eid1709.100915

i

Leptospirosis as Frequent Cause of Acute Febrile Illness in Southern Sri Lanka

Supporting Files

Sep 2011
By Reller, Megan E. ; Bodinayake, Champika ; Nagahawatte, Ajith ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Reller, Megan E. ; Bodinayake, Champika ; Nagahawatte, Ajith ; Devasiri, Vasantha ; Kodikara-Arachichi, Wasantha ; Strouse, John J. ; Flom, Judith E. ; Dumler, J. Stephen ; Woods, Christopher W.
Description:

To determine the proportion of fevers caused by leptospirosis, we obtained serum specimens and epidemiologic and clinical data from patients in Galle, Sri Lanka, March-October 2007. Immunoglobulin M ELISA was performed on paired serum specimens to diagnose acute (seroconversion or 4-fold titer rise) or past (titer without rise) leptospirosis and seroprevalence (acute). We compared (individually) the diagnostic yield of acute-phase specimens and clinical impression with paired specimens for acute leptospirosis. Of 889 patients with paired specimens, 120 had acute leptosoirosis and 241 had past leptospirosis. The sensitivity and specificity of acute-phase serum specimens were 17.5% (95% confidence interval [CI] 11.2%-25.5%) and 69.2% (95% CI 65.5%-72.7%), respectively, and of clinical impression 22.9% (95% CI 15.4%-32.0%) and 91.7% (95% CI 89.2%-93.8%), respectively. For identifying acute leptospirosis, clinical impression is insensitive, and immunoglobulin M results are more insensitive and costly. Rapid, pathogen-based tests for early diagnosis are needed.
Subjects:

Acute Disease Adolescent Adult Animals Cohort Studies Endemic Diseases Female Fever Humans Leptospirosis Male Middle Aged Prevalence Prospective Studies Sensitivity And Specificity Serologic Tests Young Adult Zoonoses
Source:

Emerg Infect Dis. 17(9):1678-1684.
Document Type:

Journal Article
Funding:

K23AIO83931/PHS HHS/United States
Place as Subject:

Sri Lanka
Volume:

17
Issue:

9
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:7be78953146c42ec07c81722915f6b3a56cb052c96bcfcc03571eb2ae4e110b3
Download URL:

https://stacks.cdc.gov/view/cdc/23659/cdc_23659_DS1.pdf
File Type:

[PDF - 211.70 KB ]

File Language:

English

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