Molecular Evolution of Respiratory Syncytial Virus Fusion Gene, Canada, 2006–2010

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Papenburg, Jesse ; Carbonneau, Julie ; Hamelin, Marie-Ève ; Isabel, Sandra ; Bouhy, Xavier ; Ohoumanne, Najwa ; Déry, Pierre ; Paes, Bosco A. ; Corbeil, Jacques ; Bergeron, Michel G. ; De Serres, Gaston ; Boivin, Guy
• Description:
  To assess molecular evolution of the respiratory syncytial virus (RSV) fusion gene, we analyzed RSV-positive specimens from 123 children in Canada who did or did not receive RSV immunoprophylaxis (palivizumab) during 2006-2010. Resistance-conferring mutations within the palivizumab binding site occurred in 8.7% of palivizumab recipients and none of the nonrecipients.
• Subjects:
  Cohort Studies Evolution, Molecular Gene Expression Regulation, Viral Humans Respiratory Syncytial Viruses Respiratory Syncytial Virus Infections Viral Fusion Proteins
• Source:
  Emerg Infect Dis. 18(1):120-124.
• Document Type:
  Journal Article
• Funding:
  Canadian Institutes of Health Research/Canada
• Place as Subject:
  Canada
• Location:
  North America
• Volume:
  18
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:e1d140d0aa05b694534fa182cbd6bef852facaf7e7b393e813d481816bb55fcc
• Download URL:
  https://stacks.cdc.gov/view/cdc/23622/cdc_23622_DS1.pdf
• File Type:
  [PDF - 356.25 KB ]