Molded Polymer-Coated Composite Bone Void Filler Improves Tobramycin Controlled Release Kinetics

Details

• Personal Author:
  Brooks AE ; Brooks BD ; Coats B ; Davidoff SN ; Grainger DW ; Lawson S ; Sinclair KD ; Williams AG
• Description:
  Infection remains a significant problem associated with biomedical implants and orthopedic surgeries, especially in revision total joint replacements. Recent advances in antibiotic-releasing bone void fillers (BVF) provide new opportunities to address these types of device-related orthopedic infections that often lead to substantial economic burdens and reduced quality of life. We report improvements made in fabrication and scalability of an antibiotic-releasing polycaprolactone-calcium carbonate/phosphate ceramic composite BVF using a new solvent-free, molten-cast fabrication process. This strategy provides the ability to tailor drug release kinetics from the BVF composite based on modifications of the inorganic substrate and/or the polymeric component, allowing extended tobramycin release at bactericidal concentrations. The mechanical properties of the new BVF composite are comparable to many reported BVFs and validate the relative homogeneity of fabrication. Most importantly, fabrication quality controls are correlated with favorable drug release kinetics, providing bactericidal activity to 10 weeks in vitro when the polycaprolactone component exceeds 98% w/w of the total polymer fraction. Furthermore, in a time kill study, tobramycin-releasing composite fragments inhibited S. aureus growth over 48 h at inoculums as high as 109 CFU/mL. This customizable antibiotic-releasing BVF polymer-inorganic biomaterial should provide osseointegrative and osteoconductive properties while contributing antimicrobial protection to orthopedic sites requiring the use of bone void fillers. [Description provided by NIOSH]
• Subjects:
  Anti-Bacterial Agents Communicable Diseases Occupational Health Safety
• Keywords:
  Antibacterial Agents Antibiotics Author Keywords: Bone Void Filler Bacterial Infections Biomedical Engineering Bone Disorders Controlled Release Implant Infection Joint Replacement Infection Prevention Osteomyelitis Polycaprolactone Revision Surgery Surgery Tobramycin

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• ISSN:
  1552-4973
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 8 ; Utah
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  102
• Issue:
  5
• NIOSHTIC Number:
  nn:20067375
• Citation:
  J Biomed Mater Res B Appl Biomater 2014 Jul; 102(5):1074-1083
• Contact Point Address:
  Amanda E. Brooks, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah, 84112-5820
• Email:
  amanda.brooks@pharm.utah.edu
• CAS Registry Number:
  Tobramycin (CAS RN 32986-56-4)
• Federal Fiscal Year:
  2014
• Performing Organization:
  University of Utah
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Biomedical Materials Research. Part B: Applied Biomaterials
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a05702618963eeffe2fea5ca2a3b1ba1ff71103196dfa238142d76be943d7e1c1b94696bc1399929169dc0019a0a9312e6b7de7b44c16ff3c0b7e7acbab01760
• Download URL:
  https://stacks.cdc.gov/view/cdc/231434/cdc_231434_DS1.pdf
• File Type:
  [PDF - 794.63 KB ]