Influence of Impurities from Manufacturing Process on the Toxicity Profile of Boron Nitride Nanotubes (Dataset)

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  The toxicity of boron nitride nanotubes (BNNTs) is confounded by the various manufacturing and purification strategies employed targeted to remove 30-60% of the residuals and impurities. Four BNNTs manufactured by the induction thermal plasma process allowed us to assess the influence of these residuals/impurities on the toxicity profile of BNNTs by producing a gradient of BNNT purity levels through sequential gas purification, and water and solvent washing, followed by filtration. Extensive characterization including Infrared, x-ray spectroscopy, thermogravimetric analysis, size, charge, surface area and density allowed characterization of the alteration in physicochemical properties as the material went through sequential purification. The material from each step was screened using acellular and in vitro assays that evaluated general toxicity, mechanisms of toxicity and macrophage function. [Description provided by NIOSH]
• Subjects:
  Blood Macrophages Manufacturing And Industrial Facilities Occupational Health Safety
• Keywords:
  Boron Nitride Manufacturing Nanotubes Physiological Chemistry Physiological Effects Toxic Effects
• DOI:
  https://doi.org/10.26616/NIOSHRD-1063-2023-0
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20067308
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1063-2023-0, 2023 Apr; :dataset
• Contact Point Address:
  Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control & Prevention, 1000 Frederick Lane (Mailstop 2015) Morgantown, WV 26508
• CAS Registry Number:
  Boron nitride (CAS RN 10043-11-5)
• Federal Fiscal Year:
  2023
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  Influence of impurities from manufacturing process on the toxicity profile of boron nitride nanotubes
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d0cae29c46ceade75e42bed817c831f5af6286b50171d21b8140ff90f321975bdfd06d9563f74ed5e5f9dd03867eba42775747394ee005b4213af06472f9b5bf
• Download URL:
  https://stacks.cdc.gov/view/cdc/231399/cdc_231399_DS1.pdf
• File Type:
  [PDF - 168.19 KB ]