Influence of Impurities from Manufacturing Process on the Toxicity Profile of Boron Nitride Nanotubes (Dataset)

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Download the Dataset decsribed here from Data.cdc.gov at https://doi.org/10.26616/NIOSHRD-1063-2023-0. ; The toxicity of boron nitride nanotubes (BNNTs) is confounded by the various manufacturing and purification strategies employed targeted to remove 30-60% of the residuals and impurities. Four BNNTs manufactured by the induction thermal plasma process allowed us to assess the influence of these residuals/impurities on the toxicity profile of BNNTs by producing a gradient of BNNT purity levels through sequential gas purification, and water and solvent washing, followed by filtration. Extensive characterization including Infrared, x-ray spectroscopy, thermogravimetric analysis, size, charge, surface area and density allowed characterization of the alteration in physicochemical properties as the material went through sequential purification. The material from each step was screened using acellular and in vitro assays that evaluated general toxicity, mechanisms of toxicity and macrophage function. Description provided by NIOSH
• Subjects:
  • Blood
  • Macrophages
  • Manufacturing and Industrial Facilities
  • Occupational Health
  • Safety
• Keywords:
  • Boron nitride
  • Nanotubes
  • Toxic effects
  • Physiological effects
  • Macrophages
  • Physiological chemistry
  • Manufacturing
• Series:
  NIOSH Data
• DOI:
  https://doi.org/10.26616/NIOSHRD-1063-2023-0
• Landing Page:
  https://stacks.cdc.gov/view/cdc/231399
• Dataset Download URL:
  https://data.cdc.gov/download/4u7c-2g4q/application%2Fx-zip-compressed
• Identifier:
  https://doi.org/10.26616/NIOSHRD-1063-2023-0
• Format:
  ZIP folder
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  OSHA Region 3 ; West Virginia
• Media Type:
  application/zip
• Described By Type:
  HTML Repository Page
• License:
  https://creativecommons.org/public-domain/
• Rights:
  Public Domain
• Described By:
  https://stacks.cdc.gov/view/cdc/231399
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Contact Point:
  Health Effects Laboratory Division (HELD). Pathology and Physiology Research Branch (PPRB)
• Pages in Document:
  1 ZIP folder
• NIOSHTIC Number:
  nn:20067308
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1063-2023-0, 2023 Apr; :dataset
• Email:
  sa-cin-webteam@cdc.gov
• CAS Registry Number:
  • Boron nitride (CAS RN 10043-11-5)
• Federal Fiscal Year:
  2023
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Download URL:
  https://stacks.cdc.gov/view/cdc/231399/cdc_231399_DS1.pdf
• File Type:
  [PDF - 168.19 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d0cae29c46ceade75e42bed817c831f5af6286b50171d21b8140ff90f321975bdfd06d9563f74ed5e5f9dd03867eba42775747394ee005b4213af06472f9b5bf