Traffic-Related Air Pollution, Biomarkers of Metabolic Dysfunction, Oxidative Stress, and CC16 in Children

Details

• Personal Author:
  Balmes JR ; Hammond SK ; Holland N ; Holm SM ; Lurmann F ; Lutzker L ; Mann JK ; Margolis HG ; Noth EM ; Tyner T ; Zhang AL
• Description:
  Background: Previous research has revealed links between air pollution exposure and metabolic syndrome in adults; however, these associations are less explored in children. Objective: This study aims to investigate the association between traffic-related air pollutants (TRAP) and biomarkers of metabolic dysregulation, oxidative stress, and lung epithelial damage in children. Methods: We conducted cross-sectional analyses in a sample of predominantly Latinx, low-income children (n = 218) to examine associations between air pollutants (nitrogen dioxide (NO2), nitrogen oxides (NOx), elemental carbon, polycyclic aromatic hydrocarbons, carbon monoxide (CO), fine particulates (PM2.5)) and biomarkers of metabolic function (high-density lipoprotein (HDL), hemoglobin A1c (HbA1c), oxidative stress (8-isoprostane), and lung epithelial damage (club cell protein 16 (CC16)). Results: HDL cholesterol showed an inverse association with NO2 and NOx, with the strongest relationship between HDL and 3-month exposure to NO2 (-15.4 mg/dL per IQR increase in 3-month NO2, 95% CI = -27.4, -3.4). 8-isoprostane showed a consistent pattern of increasing values with 1-day and 1-week exposure across all pollutants. Non-significant increases in % HbA1c were found during 1-month time frames and decreasing CC16 in 3-month exposure time frames. Conclusion: Our results suggest that TRAP is significantly associated with decreased HDL cholesterol in longer-term time frames and elevated 8-isoprostane in shorter-term time frames. TRAP could have the potential to influence lifelong metabolic patterns, through metabolic effects in childhood. [Description provided by NIOSH]
• Subjects:
  Air Pollution Biomarkers Epidemiology Healthcare Disparities Lung Occupational Health Particulate Matter Respiratory System Safety
• Keywords:
  Air Pollution Author Keywords: Traffic-related Air Pollution Automotive Emissions Children Cross Sectional Studies Early Life Childhood Exposure Health Disparities Low-SES Populations Lung Irritants Metabolic Disorders Metabolic Dysregulation Oxidative Stress Particulates Polycyclic Aromatic Hydrocarbons

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• ISSN:
  1559-0631
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  32
• Issue:
  4
• NIOSHTIC Number:
  nn:20067267
• Citation:
  J Expo Sci Environ Epidemiol 2022 Jul; 32(4):530-537
• Contact Point Address:
  Stephanie M. Holm, Division of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, CA, USA
• Email:
  stephaniemholm@berkeley.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Exposure Science and Environmental Epidemiology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3857806bb05e50b9dabf5613caef33d51498589ee91ccc07b6ce99843536e9af6deabde8ce296b194ad617eac6d835f4ff49274fdebedb03b89f808b129a1196
• Download URL:
  https://stacks.cdc.gov/view/cdc/231380/cdc_231380_DS1.pdf
• File Type:
  [PDF - 727.21 KB ]