Traffic-Related Air Pollution Is Associated with Glucose Dysregulation, Blood Pressure, and Oxidative Stress in Children

Details

• Personal Author:
  Balmes JR ; Costello S ; Eisen EA ; Hammond SK ; Holland N ; Holm SM ; Lurmann F ; Lutzker L ; Mann JK ; Margolis HG ; Nadeau K ; Neophytou AM ; Noth EM ; Prunicki M ; Tindula G ; Tyner T
• Description:
  Background: Metabolic syndrome increases the risk of cardiovascular disease in adults. Antecedents likely begin in childhood and whether childhood exposure to air pollution plays a contributory role is not well understood. Objectives: To assess whether children's exposure to air pollution is associated with markers of risk for metabolic syndrome and oxidative stress, a hypothesized mediator of air pollution-related health effects. Methods: We studied 299 children (ages 6-8) living in the Fresno, California area. At a study center visit, questionnaire and biomarker data were collected. Outcomes included hemoglobin A1c (HbA1c), urinary 8-isoprostane, systolic blood pressure (SBP), and BMI. Individual-level exposure estimates for a set of four pollutants that are constituents of traffic-related air pollution (TRAP) - the sum of 4-, 5-, and 6-ring polycyclic aromatic hydrocarbon compounds (PAH456), NO2, elemental carbon, and fine particulate matter (PM2.5) - were modeled at the primary residential location for 1-day lag, and 1-week, 1-month, 3-month, 6-month, and 1-year averages prior to each participant's visit date. Generalized additive models were used to estimate associations between each air pollutant exposure and outcome. Results: The study population was 53% male, 80% Latinx, 11% Black and largely low-income (6% were White and 3% were Asian/Pacific Islander). HbA1c percentage was associated with longer-term increases in TRAP; for example a 4.42 ng/m3 increase in 6-month average PAH456 was associated with a 0.07% increase (95% CI: 0.01, 0.14) and a 3.62 ug/m3 increase in 6-month average PM2.5 was associated with a 0.06% increase (95% CI: 0.01, 0.10). The influence of air pollutants on blood pressure was strongest at 3 months; for example, a 6.2 ppb increase in 3-month average NO2 was associated with a 9.4 mmHg increase in SBP (95% CI: 2.8, 15.9). TRAP concentrations were not significantly associated with anthropometric or adipokine measures. Short-term TRAP exposure averages were significantly associated with creatinine-adjusted urinary 8-isoprostane. Discussion: Our results suggest that both short- and longer-term estimated individual-level outdoor residential exposures to several traffic-related air pollutants, including ambient PAHs, are associated with biomarkers of risk for metabolic syndrome and oxidative stress in children. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution Biomarkers Blood Hematologic Diseases Hydrocarbons Minority Health Occupational Health Particulate Matter Polycyclic Aromatic Hydrocarbons Safety

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• Keywords:
  Air Pollutants Air Pollution Aromatic Hydrocarbons Author Keywords: Children Blood Pressure Blood Sugar Disorders Cardiovascular System Children HbA1c Metabolic Disorders Metabolic Syndrome Minority Health Oxidative Stress Particulates Polycyclic Aromatic Hydrocarbons Traffic-related Air Pollution

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• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  195
• NIOSHTIC Number:
  nn:20062377
• Citation:
  Environ Res 2021 Apr; 195:110870
• Contact Point Address:
  John R. Balmes, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA
• Email:
  jbalmes@berkeley.edu
• CAS Registry Number:
  Carbon (CAS RN 7440-44-0) ; Nitrogen dioxide (CAS RN 10102-44-0)
• Federal Fiscal Year:
  2021
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7ba598d07cdc8483646509364859caca9e80b9344fb3b942c10b768b05be775f2ddfaf8ed4df137fd05836fc2724e20d1ecb6168243098d6e1d751de5a7e76fc
• Download URL:
  https://stacks.cdc.gov/view/cdc/225640/cdc_225640_DS1.pdf
• File Type:
  [PDF - 1.67 MB ]