Race-Specific Associations of Urinary Phenols and Parabens with Adipokines in Midlife Women: The Study of Women’s Health Across the Nation (SWAN)

Details

• Personal Author:
  Herman WH ; Karvonen-Gutierrez C ; Lee, Stephen A. ; Mukherjee B ; Park SK
• Description:
  Adipokines, cytokines secreted by adipose tissue, may contribute to obesity-related metabolic disease. The role of environmental phenols and parabens in racial difference in metabolic disease burden has been suggested, but there is limited evidence. We examined the cross-sectional associations of urinary phenols and parabens with adipokines and effect modification by race. Urinary concentrations of 6 phenols (bisphenol-A, bisphenol-F, 2,4-diclorophenol, 2,5-diclorophenol, triclosan, benzophenone-3) and 4 parabens (methyl-paraben, ethyl-paraben, propyl-paraben, butyl-paraben) were measured in 2002-2003 among 1200 women (mean age = 52.6) enrolled in the Study of Women's Health Across the Nation Multi-Pollutant Study. Serum adipokines included adiponectin, high molecular weight (HMW)-adiponectin, leptin, soluble leptin receptor (sOB-R). Linear regression models were used to estimate the adjusted percentage change in adipokines per inter-quantile range (IQR) increase in standardized and log-transformed levels of individual urinary phenols and parabens. Bayesian kernel machine regression (BKMR) was used to evaluate the joint effect of urinary phenols and parabens as mixtures. Participants included white (52.5%), black (19.3%), and Asian (28.1%) women. Urinary 2,4-dichlorophenol was associated with 6.02% (95% CI: 1.20%, 10.83%) higher HMW-adiponectin and urinary bisphenol-F was associated with 2.60% (0.48%, 4.71%) higher sOB-R. Urinary methyl-paraben was associated with lower leptin in all women but this association differed by race: 8.58% (-13.99%, -3.18%) lower leptin in white women but 11.68% (3.52%, 19.84%) higher leptin in black women (P interaction = 0.001). No significant associations were observed in Asian women. Additionally, we observed a significant positive overall effect of urinary phenols and parabens mixtures in relation to leptin levels in black, but not in white or Asian women. Urinary bisphenol-F, 2,4-dichlorophenol and methyl-paraben may be associated with favorable profiles of adipokines, but methyl-paraben, widely used in hair and personal care products, was associated with unfavorable leptin levels in black women. Future studies are needed to confirm this racial difference. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Environmental Exposure Epidemiology Healthcare Disparities Occupational Health Phenol Race Factors Safety Women
• Keywords:
  Adipokines Adiponectin Adipose Tissue Author Keywords: Phenols Cohort Studies Cytokines Environmental Disparities Environmental Exposure Health Disparities Leptin Longitudinal Study Metabolic Disorders Midlife Women Parabens Phenols Racial Factors

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• ISSN:
  0269-7491
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  303
• NIOSHTIC Number:
  nn:20067255
• Citation:
  Environ Pollut 2022 Jun; 303:119164
• Contact Point Address:
  Sung Kyun Park, Department of Epidemiology School of Public Health, University of Michigan 1415 Washington Heights Ann Arbor, MI, 48109, United States
• Email:
  sungkyun@umich.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Pollution
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2aeeff3c29c0ea570a9d0c24646b7226d687f56f97530b49a71781885c803e18e852f842930341846deaef38b2305fb40bb6cd6a678927526fcc24d1bbc7a030
• Download URL:
  https://stacks.cdc.gov/view/cdc/231370/cdc_231370_DS1.pdf
• File Type:
  [PDF - 1.67 MB ]