Urinary Concentrations of Phenols and Parabens and Incident Diabetes in Midlife Women: The Study of Women’s Health Across the Nation

Details

• Personal Author:
  Harlow SD ; Herman WH ; Karvonen-Gutierrez CA ; Lee, Stephen A. ; Mukherjee B ; Park SK
• Description:
  Background: Environmental phenols have been suggested as diabetogens but evidence from prospective cohort studies is limited. We examined associations between urinary concentrations of phenols and parabens, assessed at two time-points, and incident diabetes in the Study of Women's Health Across the Nation (SWAN). Methods: We examined 1,299 women, aged 45-56 years, who were diabetes-free at baseline of the SWAN Multi-Pollutant Study (MPS) (1999-2000) and were followed through January 2017. Urinary concentrations of bisphenol-A, bisphenol-F, triclosan, 2,4-dichlorophenol, 2,5-dichlorophenol, benzophenone-3, methyl-paraben, ethyl-paraben, propyl-paraben, and butyl-paraben were measured twice at MPS baseline and 3 years later (2002-2003), and the two average concentrations were used as exposure variables. Associations of incident diabetes with individual phenols and parabens were examined using Cox regression. We evaluated the overall joint effects using quantile-based g-computation. Results: Adjusted hazard ratios (HRs) for incident diabetes of the third tertile compared with the first tertile of urinary concentrations were 0.40 (95% confidence interval [CI] = 0.29, 0.56) for methyl-paraben; 0.42 (0.30, 0.58) for propyl-paraben; 0.53 (0.38, 0.75) for 2,5-diclrorophenol; and 0.55 (0.39, 0.80) for benzophenone-3. Nonlinear associations were found for bisphenol-A and 2,4-dichlorophenol (significant positive associations in the second tertile but no associations in the third tertile compared with the first tertile). No significant associations were observed for the other individual chemicals or the joint effect of mixtures. Conclusions: Our findings do not support diabetogenic effects of urinary parabens which were inversely associated with incident diabetes among mid-life women. Epidemiologic findings for biomarkers with short half-lives and high within-person variability need to be interpreted with caution. [Description provided by NIOSH]
• Subjects:
  Biomarkers Blood Cohort Studies Environmental Exposure Epidemiology Hematologic Diseases Occupational Health Phenol Safety Women
• Keywords:
  Author Keywords: Environmental Phenols Blood Sugar Disorders Cohort Studies Diabetes Environmental Exposure Longitudinal Study Midlife Women Mixed Exposures Mixture Parabens Phenols

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• ISSN:
  2474-7882
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  5
• Issue:
  5
• NIOSHTIC Number:
  nn:20067964
• Citation:
  Environ Epidemiol 2021 Oct; 5(5):e171
• Contact Point Address:
  Sung Kyun Park, Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109
• Email:
  sungkyun@umich.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Epidemiology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6140ea3de9d5dbe2afdb492373f76db7088ae507180b29e0157d9aa920ff4427b28362ffb1b2c62d4331527344c346e84a9722464b0f6c22b890624e0a22890b
• Download URL:
  https://stacks.cdc.gov/view/cdc/230196/cdc_230196_DS1.pdf
• File Type:
  [PDF - 785.64 KB ]