Persisting Cryptococcus Yeast Species Vishniacozyma victoriae and Cryptococcus neoformans Elicit Unique Airway Inflammation in Mice Following Repeated Exposure (Dataset)

Details

• Personal Author:
  Blackwood CB ; Croston TL ; Green, Brett J. ; Lemons, Angela R. ; Rush RE
• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Download the Dataset decsribed here from Data.cdc.gov at https://doi.org/10.26616/NIOSHRD-1061-2023-0.
  
  Allergic airway diseases are a growing concern in industrialized nations and can be influenced by fungal exposures. Pathogenic yeast species such as Cryptococcus neoformans are known to exacerbate allergic airway disease. Recent indoor assessments have identified Basidiomycota yeasts, including non-pathogenic species such as Vishniacozyma victoriae (syn. Cryptococcus victoriae), to be prevalent and potentially associated with asthma. However, the pulmonary immune response to repeated V. victoriae exposure was previously unexplored. This study aimed to compare the immunological impact of repeated pulmonary exposure to pathogenic and non-pathogenic Cryptococcus yeasts. Mice were repeatedly exposed to either C. neoformans, V. victoriae, or PBS control, and the immune responses were analyzed by measuring histopathological scores, and quantifications of immune cells in the bronchoalveolar lavage fluid or lung via flow cytometry, and cytokine concentrations in the lung. These findings highlight the importance of in vivo characterizations of exposures to frequently detected fungal organisms. [Description provided by NIOSH]
  
  
• Subjects:
  Animals Asthma Asthma, Occupational Fungi Hypersensitivity Immune System Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Allergic Reactions Animal Studies Fungal Infections Immune Reaction Inhalation Studies Pulmonary Effects Respiratory Diseases Yeasts
• Series:
  NIOSH Data
• DOI:
  https://doi.org/10.26616/NIOSHRD-1061-2023-0
• Landing Page:
  https://stacks.cdc.gov/view/cdc/231329
• Dataset Download URL:
  https://data.cdc.gov/download/cygf-tgyd/application%2Fx-zip-compressed
• Identifier:
  https://doi.org/10.26616/NIOSHRD-1061-2023-0
• Format:
  ZIP folder
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  OSHA Region 3 ; West Virginia
• Media Type:
  application/zip
• Described By Type:
  HTML Repository Page
• License:
  https://creativecommons.org/public-domain/
• Rights:
  Public Domain
• Described By:
  https://stacks.cdc.gov/view/cdc/231329
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Contact Point:
  Health Effects Laboratory Divsion (HELD). Allergy and Clinical Immunology Branch (ACIB)
• Pages in Document:
  1 ZIP folder
• NIOSHTIC Number:
  nn:20067191
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1061-2023-0, 2023 Mar; :dataset
• Email:
  sa-cin-webteam@cdc.gov
• Federal Fiscal Year:
  2023
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b2d8e7346e20023c38a23546b51e9c3d546931098ddcfc5b39a5717cb002260b9d97e6e588ab2307f6239e60565466a20fdbee4b1beecaee95121b88436ad8b9
• Download URL:
  https://stacks.cdc.gov/view/cdc/231329/cdc_231329_DS1.pdf
• File Type:
  [PDF - 98.29 KB ]