In Vivo Quantification of Strontium in Bone Among Adults Using Portable X-Ray Fluorescence

Details

• Personal Author:
  Nie LH ; Specht AJ ; Weisskopf MG ; Wells EM ; Weuve J ; Zhang X
• Description:
  Background and objective: Bone strontium (Sr) is a reliable biomarker for studying related bone health outcomes and the effectiveness of Sr supplements in osteoporosis disease treatment. In this study, we evaluated the sensitivity of portable x-ray fluorescence (XRF) technology for in vivo bone Sr quantification among adults. Materials and methods: Sr-doped bone-equivalent phantoms were used for system calibration. Using the portable XRF, we measured bone Sr levels in vivo in mid-tibia bone in 76 adults, 38-95 years of age, living in Indiana, US; we also analyzed bone data of 29 adults, 53-82 years of age, living in Shanghai, China. The same portable XRF device and system settings were used in measuring their mid-tibia bone. We compared bone Sr concentrations by sex, age, and recruitment site. We also used multiple linear regression model to estimate the association of age with bone Sr concentration, adjusting for sex and recruitment site. Results: The uncertainty of in vivo individual measurement increased with higher soft tissue thickness overlying bone, and it ranged from 1.0 ug/g dry bone (ppm) to 2.4 ppm with thickness ranging from 2 to 7 mm, with a measurement time of 5 min. Geometric mean (95% confidence interval (CI)) of the bone Sr concentration was 79.1 (70.1, 89.3) ppm. After adjustment for recruitment site and sex, an increase in five years of age was associated with a 8.9% (95% CI: 2.5%, 15.6%) increase in geometric mean bone Sr concentration. Discussion and conclusion: Sr concentrations were consistently well above detection limits of the portable XRF, and exhibited an expected increase with age. These data suggest that the portable XRF can be a valuable technology to quantify Sr concentration in bone, and in the study of Sr-related health outcomes among adults, such as bone mineral density (BMD) and bone fracture risk. [Description provided by NIOSH]
• Subjects:
  Aging Biomarkers Occupational Health Safety
• Keywords:
  Author Keywords: Biomonitoring Biomonitoring Bone Disorders In Vivo Quantification In Vivo Studies Strontium Strontium In Bone X-ray Fluorescence X-ray Fluorescence Analysis
• ISSN:
  0946-672X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Indiana ; Massachusetts ; New Jersey ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  74
• NIOSHTIC Number:
  nn:20067163
• Citation:
  J Trace Elem Med Biol 2022 Dec; 74:127077
• Contact Point Address:
  Linda H. Nie, School of Health Sciences, Purdue University, 550 Stadium Mall Drive, West Lafayette, IN 47906, USA
• Email:
  hnie@purdue.edu
• CAS Registry Number:
  Strontium (CAS RN 7440-24-6)
• Federal Fiscal Year:
  2023
• Performing Organization:
  Purdue University, West Lafayette, Indiana
• Peer Reviewed:
  True
• Start Date:
  20010701
• Source Full Name:
  Journal of Trace Elements in Medicine and Biology
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9e2f6a8e87ec7adde4115715b3cd6995d867cebc427e6185f133f9d0b75793fd5c62dd20ce7f99b98711c2e7969b034bf11c946cfaed69b3db56979f2b83dd0a
• Download URL:
  https://stacks.cdc.gov/view/cdc/231308/cdc_231308_DS1.pdf
• File Type:
  [PDF - 777.99 KB ]