Portable X-Ray Fluorescence for Bone Lead Measurement: Current Approaches and Future Directions

Details

• Personal Author:
  Grier T ; Hoover C ; Specht AJ
• Description:
  Purpose of Review: Legacy lead exposures persist as a widespread problem. Blood lead is traditionally used for lead exposure surveillance; however, bone lead proves to be a cheaper, more accessible, and more revealing tool for surveillance that can be measured using portable x-ray fluorescence techniques. We outline how this approach excels for bone lead measurements. Recent Findings: Portable XRF offers quick, non-invasive in vivo quantification of bone lead. Compared to traditional KXRF systems, pXRF is limited to cortical bone but allows for quicker and similar results. Current methodologies of lead exposure need re-evaluation as lead-related disease burden and trends are dependent on both cumulative and acute impacts. Summary: We examined the evolution of XRF techniques for measuring bone lead, comparing current methods with previous ones. We assessed their accuracy, identified limitations, and discussed potential advances in future techniques. Legacy lead exposures call for a revitalization of lead surveillance methods, and pXRF measurement of bone lead offers such a solution. [Description provided by NIOSH]
• Subjects:
  Biomarkers Lead Metals, Heavy Occupational Health Safety
• Keywords:
  Analytical Instruments Author Keywords: Heavy Metals Exposure Assessment Heavy Metals In Vivo Quantification In Vivo Studies Portable Surveillance X-ray Fluorescence X-ray Fluorescence Analysis
• ISSN:
  2196-5412
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Indiana ; Massachusetts ; OSHA Region 1 ; OSHA Region 5 ; Rhode Island
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  443-451
• Volume:
  11
• Issue:
  3
• NIOSHTIC Number:
  nn:20069739
• Citation:
  Curr Environ Health Rep 2024 Sep; 11(3):443-451
• Contact Point Address:
  Aaron J. Specht, School of Health Sciences, Purdue University, 550 Stadium Mall Drive, West Lafayette, IN, 47907, USA
• Email:
  aspecht@purdue.edu
• Federal Fiscal Year:
  2024
• Performing Organization:
  Purdue University
• Peer Reviewed:
  True
• Start Date:
  20210901
• Source Full Name:
  Current Environmental Health Reports
• End Date:
  20220731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a3a86401430dfdb44096a1bd81d1d4e5f9f48139769fd34f999e104e7c1b2592a0d74f4dde55cde060cc157892cb3d8c225b35ba7d892bbf6bd7fb672703669a
• Download URL:
  https://stacks.cdc.gov/view/cdc/208101/cdc_208101_DS1.pdf
• File Type:
  [PDF - 714.38 KB ]