Exposure to the Antimicrobial Chemical Triclosan Disrupts Keratinocyte Function and Skin Integrity in a Model of Reconstructed Human Epidermis (Dataset)

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Triclosan is an antimicrobial chemical incorporated into products that are applied to the skin of healthcare workers. Exposure to triclosan has previously been shown to be immunomodulatory and associated with allergic disease. Additionally, we have shown that exposure to triclosan dermally activates the NLRP3 inflammasome and disrupts the skin barrier integrity in mice. The skin is the largest organ in the body and plays an important role as a physical barrier and regulator of the immune system. Alterations in the barrier and immune regulatory functions of the skin have been demonstrated to increase the risk of sensitization and development of allergic disease. In this study, the impact of triclosan exposure on the skin barrier and keratinocyte function was investigated using a model of reconstructed human epidermis. The apical surface of reconstructed human epidermis was exposed to triclosan once for 6, 24, or 48 hours or daily for 5 consecutive days. [Description provided by NIOSH]
• Subjects:
  Hypersensitivity Immune System Occupational Health Safety Skin
• Keywords:
  Allergic Reactions Allergies Antimicrobials Cytokines Gene Expression Immune Reaction Immune System Immunological Tests Sensitization Skin Irritants
• DOI:
  https://doi.org/10.26616/NIOSHRD-1054-2023-0
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20066883
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1054-2023-0, 2023 Jan; :dataset
• Contact Point Address:
  Allergy and Clinical Immunology Branch (ACIB), Health Effects Laboratory Division (HELD), National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV. Phone: 304.285.6024
• CAS Registry Number:
  Triclosan (CAS RN 3380-34-5)
• Federal Fiscal Year:
  2023
• NORA Priority Area:
  Healthcare and Social Assistance ; Oil and Gas Extraction
• Peer Reviewed:
  False
• Source Full Name:
  Exposure to the antimicrobial chemical triclosan disrupts keratinocyte function and skin integrity in a model of reconstructed human epidermis
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e0b660987feb17131255a5d61da54279d3cddc4de550a6707d165df4f6a6bf2381dd26f7e6fa85d1925f6217dd78226f4b7bac222a1906520ac3797fda5da0cd
• Download URL:
  https://stacks.cdc.gov/view/cdc/231187/cdc_231187_DS1.pdf
• File Type:
  [PDF - 157.32 KB ]