Physical Activity and Individual Plasma Phospholipid SFAs in Pregnancy: A Longitudinal Study in a Multiracial/Multiethnic Cohort in the United States

Details

• Personal Author:
  Chen L ; Dai J ; Fei Z ; Liu X ; Rahman ML ; Tsai MY ; Weir NL ; Wu J ; Xia, T. ; Zhang C ; Zhao SK ; Zhu Y
• Description:
  Background: Circulating individual SFAs in pregnant females are critical for maternal and fetal health. However, research on identifying their modifiable factors is limited. Objectives: We aimed to examine the associations of total physical activity (PA) and types of PA with circulating individual SFAs during pregnancy in a multiracial/multiethnic cohort of pregnant females in the United States. Methods: The study included participants in a nested case-control study (n = 321) from the Eunice Kennedy Shriver NICHD Fetal Growth Studies-Singleton Cohort. Sampling weights were applied, so the results represented the entire Fetal Growth Cohort. Plasma phospholipid SFAs were measured at 4 visits [10-14 (visit 1), 15-26 (visit 2), 23-31 (visit 3), and 33-39 (visit 4) weeks of gestation] throughout pregnancy. PA of the previous year at visit 1 and since the previous visit at the subsequent visits was assessed using the validated Pregnancy PA Questionnaire. Time-specific and longitudinal associations were examined using multivariable linear and generalized estimating equation models. Results: Total PA (metabolic equivalent of task-h/wk) was positively associated with circulating heptadecanoic acid (17:0) at visit 1 (β × 103: 0.07; 95% CI: 0.02, 0.11) and pentadecanoic acid (15:0) at visit 3 (β × 103: 0.09; 95% CI: 0.03, 0.14) independent of sociodemographic, reproductive, pregnancy, and dietary factors. Across the 4 visits, the positive associations with total PA were consistent for pentadecanoic acid (β × 103: 0.06; 95% CI: 0.02, 0.10) and heptadecanoic acid (β × 103: 0.10; 95% CI: 0.06, 0.14). Out of the 4 PA types (i.e., sports/exercise, household/caregiving, transportation, and occupational PA) considered, the magnitude of positive associations was the largest for sports/exercise PA. Conclusions: Our findings suggest that maternal PA is positively associated with circulating pentadecanoic and heptadecanoic acids. The findings warrant confirmation by future studies. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Occupational Health Pregnancy Safety Women
• Keywords:
  Author Keywords: Saturated Fatty Acids Cohort Studies Fatty Acids Longitudinal Study Maternal Exercise PA Physical Activity Physical Exercise Pregnancy Health Pregnant Females Prospective Cohort SFAs

  More +
• ISSN:
  0002-9165
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Maryland ; Minnesota ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  116
• Issue:
  6
• NIOSHTIC Number:
  nn:20066654
• Citation:
  Am J Clin Nutr 2022 Dec; 116(6):1729-1737
• Contact Point Address:
  Cuilin Zhang, Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
• Email:
  obgzc@nus.edu.sg
• Federal Fiscal Year:
  2023
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  The American Journal of Clinical Nutrition
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8314449a8898a9c78a2d499c8870786a768d1a9847bd6e098db1cf2d55198df5dd75bcf30faf6e74bee6ecd3d5a2055c7be4c6eff9664d4e88bd63f8cf51aa79
• Download URL:
  https://stacks.cdc.gov/view/cdc/231148/cdc_231148_DS1.pdf
• File Type:
  [PDF - 183.47 KB ]